Strain Data Sheet

RBRC02846

Strain Information

Image
BRC No.RBRC02846
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6/SvEvTac-Crx<tm1Clc>
Former Common nameCRX K.O.
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain129S6/SvEvTac
Appearancelight-bellied agouti [A<w>/A<w> B/B C/C]
Strain developmentDeveloped by Dr. Takahisa Furukawa, Harvard Medical School in 1999.
Strain descriptionCrx gene knockout mice. Homozygous mutant mice lack a outer segment of retinal photoreceptor.
Colony maintenanceSibling x Sibling (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile
References
Retinopathy and attenuated circadian entrainment in Crx-deficient mice.
Furukawa T, Morrow E M, Li T, Davis F C, Cepko C L
Nat. Genet., 23, 466-470 (1999). 10581037

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Crxcone-rod homeobox7Crxtargeted mutation 1, Constance L Cepko
  • cone-rod dystrophy 2(DisGeNET, MedGEN)

  • Leber congenital amaurosis 7(DisGeNET, MedGEN)

  • Leber congenital amaurosis(DisGeNET)
    • more 1 Diseases
  • retinitis pigmentosa(DisGeNET, MedGEN)
    • neoneomycin resistance gene (E. coli)7mouse phosphoglycerate kinase promoter (PGK promoter)
  • cone-rod dystrophy 2(DisGeNET, MedGEN)

  • Leber congenital amaurosis 7(DisGeNET, MedGEN)

  • Leber congenital amaurosis(DisGeNET)
    • more 1 Diseases
  • retinitis pigmentosa(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal circadian behavior(MP:0020467)

  • abnormal cone electrophysiology(MP:0004022)

  • abnormal electroretinogram waveform feature(MP:0012029)

  • abnormal eye electrophysiology(MP:0005551)

  • abnormal photoreceptor inner segment morphology(MP:0003730)
    • more 16 phenotypes
  • abnormal photoreceptor outer segment morphology(MP:0003729)

  • abnormal retina bipolar cell morphology(MP:0006073)

  • abnormal retina cone bipolar cell morphology(MP:0006075)

  • abnormal retina horizontal cell morphology(MP:0006068)

  • abnormal retina layer morphology(MP:0003727)

  • abnormal retina morphology(MP:0001325)

  • abnormal retina outer plexiform layer morphology(MP:0003732)

  • abnormal retina photoreceptor layer morphology(MP:0003728)

  • abnormal retina photoreceptor morphology(MP:0001004)

  • abnormal retina rod bipolar cell morphology(MP:0006074)

  • abnormal rod electrophysiology(MP:0004021)

  • absent photoreceptor outer segment(MP:0008585)

  • delayed circadian behavior phase(MP:0020475)

  • retina outer nuclear layer degeneration(MP:0008518)

  • thin retina outer nuclear layer(MP:0008515)

  • vision/eye phenotype(MP:0005391)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, SV40 polyA, mouse Crx genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Genet., 23, 466-470 (1999).
    DepositorTakahisa Furukawa (Osaka Bioscience Institute)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Iura Y, Udo H.
    Behavioral analyses of visually impaired Crx knockout mice revealed sensory compensation in exploratory activities on elevated platforms.
    Behav Brain Res 258 1-7(2014) 24140563