RBRC02846

Information1

Image
BRC No.RBRC02846
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6/SvEvTac-Crx<tm1Clc>
Former Common nameCRX K.O.
H-2 Haplotype
ES Cell line
Background strain129S6/SvEvTac
Appearancelight-bellied agouti [A<w>/A<w> B/B C/C]
Strain developmentDeveloped by Dr. Takahisa Furukawa, Harvard Medical School in 1999.
Strain descriptionCrx gene knockout mice. Homozygous mutant mice lack a outer segment of retinal photoreceptor.
Colony maintenanceSibling x Sibling (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile
ReferencesNat. Genet., 23, 466-470 (1999). 10581037

Health Report

Examination Date / Room / Rack2020/06/01Room:3-BRack:K
2020/02/17Room:3-BRack:K
2020/02/03Room:3-BRack:K
2020/01/27Room:3-BRack:K
2019/12/16Room:3-BRack:K
2019/11/22Room:3-BRack:K
2019/11/18Room:3-BRack:K
2019/10/21Room:3-BRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Crxcone-rod homeobox containig gene7Crx<tm1Clc>targeted mutation 1, Constance L Cepko

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)7mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, SV40 polyA, mouse Crx genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Genet., 23, 466-470 (1999).
DepositorTakahisa Furukawa (Osaka Bioscience Institute)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
Strain AvailabilityCryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Iura Y, Udo H.
Behavioral analyses of visually impaired Crx knockout mice revealed sensory compensation in exploratory activities on elevated platforms.
Behav. Brain Res. (2013) 24140563