Strain Data Sheet

RBRC02825

Strain Information

Image
BRC No.RBRC02825
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129S2-Ramp1<tm1.1Tsuj>
Former Common namePAMP1-KO
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strainBALB/cAnNCrlCrlj
Appearance
Strain developmentDeveloped by K. Tsujikawa, M. Ikawa, M. Okabe, and H Yamamoto in Osaka University at 2007. BALB/c background.
Strain description
Colony maintenance
References
Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice.
Kazutake Tsujikawa, Katsutoshi Yayama, Tamon Hayashi, Hiroaki Matsushita, Taijiro Yamaguchi, Tomomi Shigeno, Yusuke Ogitani, Megumi Hirayama, Tetsuya Kato, So-ichiro Fukada, Shingo Takatori, Hiromu Kawasaki, Hiroshi Okamoto, Masahito Ikawa, Masaru Okabe, Hiroshi Yamamoto
Proc. Natl. Acad. Sci. USA, 104, 16702-16707 (2007). 17923674

Health Report

Examination Date / Room / Rack2025-02-25Room:4-BRack:BSentinel mouse program
2024-11-25Room:4-BRack:BSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ramp1
MGI:1858418		receptor (calcitonin) activity modifying protein 11Ramp1<tm1.1Tsuj>
MGI:3761144		targeted mutation 1.1, Kazutake Tsujikawa
loxP phage P1 loxP1loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal chemokine secretion (MP:0008722)

  • abnormal cytokine secretion (MP:0003009)

  • decreased vasodilation (MP:0005591)

  • increased circulating interferon-gamma level (MP:0008577)

  • increased circulating interleukin-6 level (MP:0008596)
    • more 2 phenotypes
  • increased circulating tumor necrosis factor level (MP:0008553)

  • increased systemic arterial systolic blood pressure (MP:0006144)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP site, Mouse Ramp1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci., USA, 104, 16702-16707 (2007). The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT agree to use the BIOLOGICAL RESOURCE as the collaboration with the DEPOSITOR.
    DepositorHiroshi Yamamoto (The University of Osaka)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Miki K, Takeshita N, Yamashita M, Kitamura M, Murakami S.
    Calcitonin gene-related peptide regulates periodontal tissue regeneration.
    Sci Rep 14(1) 1344(2024) 38228723