RBRC02711

Information1

Image
BRC No.RBRC02711
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Osmr<tm1Mtan>
Former Common nameOncostatin M receptor knockout mouse, OSMR-KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Minoru Tanaka in 1999.
Strain descriptionOsmr knock-out mice. Osmr, Oncostain M receptor is an alternative subunit that activated by Osm. Osm is a multifunctional cytokine that belongs to the interleukin 6 family, considered to play a role in hematopoiesis. Homozygous mutant mice are viable and fertile, but show a mild anemia and recovery delay of erythrocytes from chemically induced acute hemolysis.
Colony maintenanceHeterozygote x Wild-type [C57BL/6CrSlc]
ReferencesBlood, 102, 3154-3162 (2003). 12855584
Hepatology, 39, 635-644 (2004). 14999682

Health Report

Examination Date / Room / Rack2020/11/16Room:3-CRack:H
2020/08/24Room:3-CRack:H
2020/06/01Room:3-CRack:H
2020/02/17Room:3-CRack:H
2019/12/16Room:3-CRack:H
2019/10/21Room:3-CRack:H
2019/08/26Room:3-CRack:H
2019/06/17Room:3-CRack:H

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Osmroncostatin M receptor15Osmr<tm1Mtan>targeted mutation 1, Minoru Tanaka

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)15

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)15herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, E. coli lacZ, mouse Osmrg genomic DNA
Research applicationFluorescent Proteins/lacZ System
Hematological Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004).The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Chiome Bioscience Inc. Email:knakamura@chiome.co.jp).
DepositorAtsushi Miyajima (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.
Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
Glia (2015) 25921393

Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H.
Oncostatin M Confers Neuroprotection against Ischemic Stroke.
J. Neurosci. 35(34) 12047-62. (2015) 26311783

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nat Commun (2017) 28067314