Strain Data Sheet


Strain Information

BRC No.RBRC02711
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Osmr<tm1Mtan>
Former Common nameOncostatin M receptor knockout mouse, OSMR-KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Minoru Tanaka in 1999.
Strain descriptionOsmr knock-out mice. Osmr, Oncostain M receptor is an alternative subunit that activated by Osm. Osm is a multifunctional cytokine that belongs to the interleukin 6 family, considered to play a role in hematopoiesis. Homozygous mutant mice are viable and fertile, but show a mild anemia and recovery delay of erythrocytes from chemically induced acute hemolysis.
Colony maintenanceHeterozygote x Wild-type [C57BL/6CrSlc]
ReferencesHepatology, 39, 635-644 (2004). 14999682
Blood, 102, 3154-3162 (2003). 12855584

Health Report

Examination Date / Room / Rack2024/04/22Room:3-CRack:H


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Osmroncostatin M receptor15Osmr<tm1Mtan>targeted mutation 1, Minoru TanakaOSMRB

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)15

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)15neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, E. coli lacZ, mouse Osmrg genomic DNA
Research applicationFluorescent Proteins/lacZ System
Hematological Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004).The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Chiome Bioscience Inc.
DepositorAtsushi Miyajima (The University of Tokyo)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B.
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
Acta Neuropathol 144(2) 259-281(2022) 35666306

Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.
Oncostatin M protects against demyelination by inducing a protective microglial phenotype.
Glia 63(10) 1729-37(2015) 25921393

Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H.
Oncostatin M Confers Neuroprotection against Ischemic Stroke.
J Neurosci 35(34) 12047-62(2015) 26311783

Feng Y, Yuan Y, Xia H, Wang Z, Che Y, Hu Z, Deng J, Li F, Wu Q, Bian Z, Zhou H, Shen D, Tang Q.
OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
J Transl Med 21(1) 290(2023) 37120549

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nat Commun 8 13946(2017) 28067314