Information1 | |
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Image | ![]() |
BRC No. | RBRC02711 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.129S-Osmr<tm1Mtan> |
Former Common name | Oncostatin M receptor knockout mouse, OSMR-KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | C57BL/6NCrSlc |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Minoru Tanaka in 1999. |
Strain description | Osmr knock-out mice. Osmr, Oncostain M receptor is an alternative subunit that activated by Osm. Osm is a multifunctional cytokine that belongs to the interleukin 6 family, considered to play a role in hematopoiesis. Homozygous mutant mice are viable and fertile, but show a mild anemia and recovery delay of erythrocytes from chemically induced acute hemolysis. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6CrSlc] |
References | Blood, 102, 3154-3162 (2003). 12855584 Hepatology, 39, 635-644 (2004). 14999682 |
Health Report | |
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Examination Date / Room / Rack | 2020/11/16Room:3-CRack:H 2020/08/24Room:3-CRack:H 2020/06/01Room:3-CRack:H 2020/02/17Room:3-CRack:H 2019/12/16Room:3-CRack:H 2019/10/21Room:3-CRack:H 2019/08/26Room:3-CRack:H 2019/06/17Room:3-CRack:H |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)15 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)15herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Information2 | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, E. coli lacZ, mouse Osmrg genomic DNA |
Research application | Fluorescent Proteins/lacZ System Hematological Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004).The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Chiome Bioscience Inc. Email:knakamura@chiome.co.jp). |
Depositor | Atsushi Miyajima (The University of Tokyo) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Lab HP (Japanese) Genotyping protocol -PCR- |
BRC mice in Publications |
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Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N. Oncostatin M protects against demyelination by inducing a protective microglial phenotype. Glia (2015) 25921393 Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H. Oncostatin M Confers Neuroprotection against Ischemic Stroke. J. Neurosci. 35(34) 12047-62. (2015) 26311783 Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun (2017) 28067314 |