RBRC02684

Information1

Image
BRC No.RBRC02684
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6J.C-Atp2b2<wri>/Oda
Former Common name
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain developmentSpontaneous mutant arose in BALB/c inbred mice, found by Mr. Michio Ohmura, Ohmura Institute for Laboratory Animals in 1984. The Wriggle mice were maintained by Dr. Nobutaka Ohsawa, Kitasato University School of Medicine, and then backcrossed to C57BL/6J by Dr. Sen-ichi Oda, Nagoya University in 2005.
Strain descriptionWriggle Mouse Sagami (wri), a point mutation was occurred in a Atp2b2 gene that is an isoform of Calmodulin-dependent plasma membrane Ca<2+>-ATPase. Homozygous mutant mice show severe dystonic movements of the trunk and extremities.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJmsSlc]Homozygous mutant mice are viable, but infertile due to a failure of mating behavior.
ReferencesBiochem. Biophys. Res. Commun., 261, 773-778 (1999). 10441500

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Atp2b2ATPase, Ca++ transporting, plasma membrane 26Atp2b2<wri>wriggle

Information2

Donor DNA
Research applicationNeurobiology Research
Sensorineural Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
DepositorSenichi Oda (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data