RBRC02598

Information1

Image
BRC No.RBRC02598
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Mutyh<tm1Yun>
Former Common nameMYH KO
H-2 Haplotype
ES Cell lineCCE28 [129/Sv]
Background strain
Appearance
Strain developmentDeveloped by Yusaku Nakabeppu, Medical Institute of Bioregulation, Kyushu University. CCE28 ES cells derived from 129/Sv were used to generate the knockout mice. The mice were crossed to C57BL/6.
Strain descriptionMYH (Mutyh) gene knockout mice. Exons 8 to 15 were replaced with a pol II neo cassette. Homozygous mutant mice show decreased susceptibility to neuronal excitotoxicity.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesJ. Biol. Chem., 278, 38121-38124 (2003). 12917422

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
MutyhmutY homolog (E. coli)4Mutyh<tm1Yun>targeted mutation 1, Yusaku Nakabeppu

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)4

Information2

Donor DNAMYH (mut Y homologue), E. coli neo, RNA polymerase II promoter, polyA
Research applicationNeurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 278, 38121-38124 (2003).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorToshikuni Sasaoka (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data