Strain Data Sheet

RBRC02595

Strain Information

Image
BRC No.RBRC02595
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Diap1<tm1Sna>/SiaRbrc
Former Common namemDia1(loxP) (Acc. No. CDB0437K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1.
Sakata D, Taniguchi H, Yasuda S, Adachi-Morishima A, Hamazaki Y, Nakayama R, Miki T, Minato N, Narumiya S
J. Exp. Med., 204, 2031-2038 (2007). 17682067

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Diap1
MGI:1194490		diaphanous homolog 1 (Drosophila)18Diap1<tm1Sna>
MGI:3761498		targeted mutation 1, Shuh Narumiya
  • autosomal dominant nonsyndromic hearing loss 1(MedGEN)

  • progressive microcephaly-seizures-cortical blindness-developmental delay syndrome(MedGEN)
    • Frt yeast FRT (flippase recombination target) site18Frt
    Frt yeast FRT (flippase recombination target) site18Frt
    loxP phage P1 loxP18loxP
    loxP phage P1 loxP18loxP
    neo neomycin resistance gene (E. coli)18 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • obsolete no phenotypic analysis (MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse PGK 3’ end, Phage P1 loxP, yeast FRT (flipase recombination target) sites
    Research applicationImmunology and Inflammation Research
    Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from Dr. Shuh NARUMIIYA (snaru@mfour.med.kyoto-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0437K and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, J Exp Med. 2007 Sep 3; 204 (9): 2031-8. (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data