Strain Data Sheet

RBRC02591

Information1

Image
BRC No.RBRC02591
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Git2<tm1Hsb>/SiaRbrc
Former Common nameGIT2(-) (Acc. No. CDB0414K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
ReferencesNat. Immunol., 7, 724-731 (2006) 16715100

Health Report

Examination Date / Room / Racknull

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Git2G protein-coupled receptor kinase-interactor 25Git2<tm1Hsb>targeted mutation 1, Hisataka Sabe1500036H07Rik, 5830420E16Rik, 9630056M03Rik, ARF GTPase activating protein 2, B230104M05Rik, Cat-2, Cool associated tyrosine phosphorylated-2

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)5neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAE. coli Neo, Phage P1 loxP、 mouse PKG promoter, mouse PKG 3’ end
Research applicationImmunology and Inflammation Research
Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from Dr. Hisataka SABE (sabe@obi.or.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0414K and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Nat Immunol. 2006 Jul; 7 (7): 724-31. (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
DepositorRIKEN CDB (RIKEN CDB)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Hao YE, He DF, Yin RH, Chen H, Wang J, Wang SX, Zhan YQ, Ge CH, Li CY, Yu M, Yang XM.
GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice.
FEBS Open Bio 5 688-704(2015) 26380813

Wei J, Wei C, Wang M, Qiu X, Li Y, Yuan Y, Jin C, Leng L, Wang J, Yang X, He F.
The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
Proc Natl Acad Sci U S A 111(24) 8883-8(2014) 24879442