RBRC02591

Information1

Image
BRC No.RBRC02591
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameGIT2(-) (Acc. No. CDB0414K)
Former Common name
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
ReferencesNat. Immunol., 7, 724-731 (2006) 16715100

Health Report

Examination Date / Room / Rack2011/12/12Room:3-CRack:F
2011/10/17Room:3-CRack:F
2011/08/29Room:3-CRack:F
2011/06/20Room:3-CRack:F
2011/04/18Room:3-CRack:F
2011/02/21Room:3-CRack:F
2010/12/13Room:3-CRack:F
2010/10/18Room:3-CRack:F

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Git2G protein-coupled receptor kinase-interactor 25Git2<tm1Hsb>targeted mutation 1, Hisataka Sabe

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)5mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAE. coli Neo, Phage P1 loxP、 mouse PKG promoter, mouse PKG 3’ end
Research applicationImmunology and Inflammation Research
Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from Dr. Hisataka SABE (sabe@obi.or.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0414K and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Nat Immunol. 2006 Jul; 7 (7): 724-31. (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
DepositorRIKEN CDB (RIKEN CDB)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Yu-E Hao, Dong-Fang He, Rong-Hua Yin, Hui Chen, Jian Wang, Shao-Xia Wang, Yi-Qun Zhan, Chang-Hui Ge, Chang-Yan Li, Miao Yu, Xiao-Ming Yanga,
GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice.
FEBS Open Bio (2015) 26380813

Wei J, Wei C, Wang M, Qiu X, Li Y, Yuan Y, Jin C, Leng L, Wang J, Yang X, He F.
The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
Proc. Natl. Acad. Sci. U.S.A. 111(24) 2549241(2014) 24879442