Strain Data Sheet
RBRC02591
Information1 | |
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| Image | |
| BRC No. | RBRC02591 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.Cg-Git2<tm1Hsb>/SiaRbrc |
| Former Common name | GIT2(-) (Acc. No. CDB0414K) |
| H-2 Haplotype | |
| ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Nat. Immunol., 7, 724-731 (2006) 16715100 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Git2G protein-coupled receptor kinase-interactor 25Git2<tm1Hsb>targeted mutation 1, Hisataka Sabe1500036H07Rik, 5830420E16Rik, 9630056M03Rik, ARF GTPase activating protein 2, B230104M05Rik, Cat-2, Cool associated tyrosine phosphorylated-2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)5neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Information2 | |
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| Donor DNA | E. coli Neo, Phage P1 loxP、 mouse PKG promoter, mouse PKG 3’ end |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | (1) The RECIPIENT shall obtain a prior agreement from Dr. Hisataka SABE (sabe@obi.or.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0414K and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Nat Immunol. 2006 Jul; 7 (7): 724-31. (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. |
| Depositor | RIKEN CDB (RIKEN CDB) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Hao YE, He DF, Yin RH, Chen H, Wang J, Wang SX, Zhan YQ, Ge CH, Li CY, Yu M, Yang XM. GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice. FEBS Open Bio 5 688-704(2015) 26380813 Wei J, Wei C, Wang M, Qiu X, Li Y, Yuan Y, Jin C, Leng L, Wang J, Yang X, He F. The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling. Proc Natl Acad Sci U S A 111(24) 8883-8(2014) 24879442 |