Strain Information | |
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Image | |
BRC No. | RBRC02573 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Traf5<tm1Hna> |
Former Common name | B6.traf5<-/->, TRAF5 KO,C57BL/6 |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Hiroshi Nakano and Haruhio Koseki in 1999. |
Strain description | Homozygous mutant mice show defects in lymphocyte activation. |
Colony maintenance | Sibling Mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile. |
References | Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, Munechika E, Sakai T, Shirasawa T, Akiba H, Kobata T, Santee S M, Ware C F, Rennert P D, Taniguchi M, Yagita H, Okumura K Proc. Natl. Acad. Sci. USA, 96, 9803-9808 (1999). 10449775Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H J. Biol. Chem., 276, 36530 (2001) 11479302TNF receptor-associated factor 5 limits the induction of Th2 immune responses. So T, Salek-Ardakani S, Nakano H, Ware C F, Croft M J. Immunol., 172, 4292-4297 (2004). 15034043 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Traf5 | TNF receptor-associated factor 5 | 1 | Traf5 | targeted mutation 1, Hiroyasu Nakano | |||
neo | neomycin resistance gene (E. coli) | 1 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | E. coli neo, mouse traf5 genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The recipient of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. |
Depositor | Hiroyasu Nakano (Juntendo University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Wang L, Lu Y, Guan H, Jiang D, Guan Y, Zhang X, Nakano H, Zhou Y, Zhang Y, Yang L, Li H. Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction. J Neurochem 126(3) 400-14(2013) 23413803 |