RBRC02573

Information1

Image
BRC No.RBRC02573
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Traf5<tm1Hna>
Former Common nameB6.traf5<-/->, TRAF5 KO,C57BL/6
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Hiroshi Nakano and Haruhio Koseki in 1999.
Strain descriptionHomozygous mutant mice show defects in lymphocyte activation.
Colony maintenanceSibling Mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile.
ReferencesJ. Immunol., 172, 4292-4297 (2004). 15034043
Proc. Natl. Acad. Sci. USA, 96, 9803-9808 (1999). 10449775
J. Biol. Chem., 276, 36530 (2001) 11479302

Health Report

Examination Date / Room / Rack2010/05/10Room:2-検Rack:E
2010/03/08Room:2-検Rack:E
2010/01/12Room:2-検Rack:E
2009/11/09Room:2-検Rack:E
2009/09/07Room:2-検Rack:E
2009/07/06Room:2-検Rack:E
2009/05/12Room:2-検Rack:E
2009/05/11Room:2-検Rack:E

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Traf5Tnf receptor-associated factor 51Traf5<tm1Hna>targeted mutation 1, Hiroyasu Nakano

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAE. coli neo, mouse traf5 genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The recipient of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
DepositorHiroyasu Nakano (Juntendo University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Wang L, Lu Y, Guan H, Jiang D, Guan Y, Zhang X, Nakano H, Zhou Y, Zhang Y, Yang L, Li H.
Tumor Necrosis Factor Receptor Associated Factor 5 is an Essential Mediator of Ischemic Brain Infarction.
J. Neurochem. (2013) 23413803