BRC No.RBRC02432
SpeciesMus musculus
Strain name(hRN8-12 x hAG2-5)F1
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background.
Strain description
Colony maintenance
ReferencesBiochemical and Biophysical Research Communications, 165, 826-832 (1989). 2480785
Biochemical and Biophysical Research Communications, 180, 1103-1109 (1991). 1659395

Health Report

Examination Date / Room / Rack2019/02/04Room:3-2Rack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
AGTAngiotensinogen (human)UNAGT

Gene symbolGene nameChr.Allele symbolAllele namePromoter
REN1renin 1 structural (human)UNREN1


Donor DNAhuman angiotensinogen genomic DNA ,human renin1 genomic DNA (10 exons, 9 introns and native promoter)
Research applicationMouse Models for Human Disease
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochemical and Biophysical Research Communications, 165, 826-832 (1989).
Biochemical and Biophysical Research Communications, 180, 1103-1109 (1991).
DepositorAkiyoshi Fukamizu (University of Tsukuba)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
Strain AvailabilityCryopreserved embryos (within 1 month)
Live mouse (3 to 6 months)
Additional Info.Genotyping protocol -PCR-
Lab HP (Japanese)
Mouse of the Month May 2012
Systolic blood pressure

BRC mice in Publications

Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A, Arakawa K.
Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice.
Biomed Rep 1(3) 359-364(2013) 24648949

Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T.
Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation.
J. Am. Soc. Nephrol. (2012) 22440899

Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A.
Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure.
PLoS ONE 12(8) e0181055(2017) 28800627