BRC No.RBRC02422
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S2-Mdk<tm1Tmu>
Former Common nameMdk-KO/C57BL/6J
H-2 Haplotype
ES Cell line
Background strain
Strain development
Strain description
Colony maintenance
ReferencesGenes Cells, 3, 811-822 (1998) 10096002
Arthritis Rheum., 50, 1420-1429 (2004). 15146411
J. Biochem., 132, 359-371 (2002). 12204104
Am. J. Pathol., 165, 1603-1612 (2004) 15509530
Am. J. Pathol., 168, 9-19 (2006) 16400005
J. Cell Sci., 117, 5405-5415 (2004) 15466886
Circulation, 114, 1713-1720 (2006) 17015789
J. Clin. Invest., 105, 489-495 (2000) 10683378

Health Report

Examination Date / Room / Rack2009/04/21Room:3-DRack:D


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Mdkmidkine2Mdk<tm1Tmu>targeted mutation 1, Takashi Muramatsu

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)2herpes simplex virus thymidine kinase promoter (HSV tk promoter)


Donor DNApolyoma virus thymidine kinase gene promoter, E. coli neomycin resistance gene, mouse Mdk genomic DNA
Research applicationCancer Research
Cell Biology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorHisako Muramatsu (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Chen H, He D, Lasek AW.
Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression.
Genes Brain Behav. 16(7) 699-708(2017) 28398003