Strain Data Sheet

RBRC02422

Strain Information

Image
BRC No.RBRC02422
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S2-Mdk<tm1Tmu>
Former Common nameMdk-KO/C57BL/6J
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Kawai H, Sato W, Yuzawa Y, Kosugi T, Matsuo S, Takei Y, Kadomatsu K, Muramatsu T
Am. J. Pathol., 165, 1603-1612 (2004) 15509530

Growth factor midkine is involved in the pathogenesis of diabetic nephropathy.
Kosugi T, Yuzawa Y, Sato W, Kawai H, Matsuo S, Takei Y, Muramatsu T, Kadomatsu K
Am. J. Pathol., 168, 9-19 (2006) 16400005

Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis.
Maruyama K, Muramatsu H, Ishiguro N, Muramatsu T
Arthritis Rheum., 50, 1420-1429 (2004). 15146411

Lazarus rises: islet regeneration in the 21st century.
Gottlieb P A
Genes Cells, 3, 811-822 (1998). 10096002

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Muramatsu H, Zou P, Suzuki H, Oda Y, Chen G Y, Sakaguchi N, Sakuma S, Maeda N, Noda M, Takada Y, Muramatsu T
J. Cell Sci., 117, 5405-5415 (2004) 15466886

Neointima formation in a restenosis model is suppressed in midkine-deficient mice.
Horiba M, Kadomatsu K, Nakamura E, Muramatsu H, Ikematsu S, Sakuma S, Hayashi K, Yuzawa Y, Matsuo S, Kuzuya M, Kaname T, Hirai M, Saito H, Muramatsu T
J. Clin. Invest., 105, 489-495 (2000) 10683378

Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis.
Muramatsu T
J. Biochem., 132, 359-371 (2002). 12204104

Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.
Horiba M, Kadomatsu K, Yasui K, Lee J K, Takenaka H, Sumida A, Kamiya K, Chen S, Sakuma S, Muramatsu T, Kodama I
Circulation, 114, 1713-1720 (2006) 17015789

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mdkmidkine2Mdktargeted mutation 1, Takashi Muramatsu
neoneomycin resistance gene (E. coli)2herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating enzyme level(MP:0001570)

  • abnormal dentate gyrus morphology(MP:0000812)

  • abnormal hearing physiology(MP:0001963)

  • abnormal hippocampus development(MP:0000808)

  • abnormal learning/memory/conditioning(MP:0002063)
    • more 16 phenotypes
  • abnormal macrophage chemotaxis(MP:0010760)

  • abnormal social investigation(MP:0001360)

  • abnormal social/conspecific interaction behavior(MP:0002557)

  • abnormal vascular endothelial cell morphology(MP:0006055)

  • abnormal wound healing(MP:0005023)

  • behavior/neurological phenotype(MP:0005386)

  • decreased dopamine level(MP:0005643)

  • decreased hepatocyte number(MP:0000606)

  • decreased liver weight(MP:0003402)

  • decreased macrophage cell number(MP:0003884)

  • decreased prepulse inhibition(MP:0009142)

  • female infertility(MP:0001926)

  • impaired neutrophil chemotaxis(MP:0008720)

  • increased anxiety-related response(MP:0001363)

  • kidney failure(MP:0003606)

  • tubular nephritis(MP:0002704)
    • Detailed phenotype data

    Ordering Information

    Donor DNApolyoma virus thymidine kinase gene promoter, E. coli neomycin resistance gene, mouse Mdk genomic DNA
    Research applicationCancer Research
    Cell Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 3, 811-822 (1998). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR (Dr. Hisako Muramatsu) is requested.
    DepositorHisako Muramatsu (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Chen H, He D, Lasek AW.
    Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression.
    Genes Brain Behav 16(7) 699-708(2017) 28398003