BRC No.RBRC02411
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S2-Ptn<tm1Tmu>
Former Common namePtn-KO/C57BL/6J
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Muramatsu H. and Muramatsu T., Nagoya University in 2001.
Strain descriptionPleiotrophin (PTN) knock-out mice, Ptn is a low molecular weight protein that regulates cell growth, survival and migration and other activities of responding cells. Ptn gene strongly expresses in the brain at the later mouse embryogenesis, In the human, it is known that the expression of Ptn gene is observed at the ischemic injury in various cancer.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc)
ReferencesLab. Invest., 86, 645-653 (2006). 16619002
Genes Cells, 11, 1405-1417 (2006). 17121547
Liver Int., 24, 484-491 (2004). 15482347
J. Biochem., 132, 359-371 (2002). 12204104

Health Report

Examination Date / Room / Rack2008/06/23Room:3-DRack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ptnpleiotrophin6Ptn<tm1Tmu>targeted mutation 1, Takashi MuramatsuHB-GAM, HBGF-8, heparin-binding growth factor 8, heparin-binding growth-associated molecule, Osf-1, Osf1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)6neo; neomycin;polyoma virus thymidine kinase gene promoter (tk promoter)


Donor DNApolyoma virus thymidine kinase gene promoter, E. coli neomycin resistance gene, mouse Ptn genomic DNA
Research applicationCancer Research
Cell Biology Research
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Liver Int., 24, 484-491 (2004). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR (Dr. Hisako Muramatsu) is requested.
DepositorHisako Muramatsu (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data