Strain Data Sheet

RBRC02401

Strain Information

Image
BRC No.RBRC02401
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Bst1<tm1Thir>
Former Common nameBST-1/CD157 KO mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Katsuhiko Ishihara and Toshio Hirano, Osaka University in 1997.
Strain descriptionCD157 (Bst1) knockout mice.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
References
Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses.
M Itoh, K Ishihara, T Hiroi, B O Lee, H Maeda, H Iijima, M Yanagita, H Kiyono, T Hirano
J. Immunol., 161, 3974-3983 (1998). 9780166

Health Report

Examination Date / Room / Rack2024-10-21Room:3-CRack:ASentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bst1
MGI:105370		bone marrow stromal cell antigen 15Bst1<tm1Thir>
MGI:3663800		targeted mutation 1, Toshio Hirano
neo neomycin resistance gene (E. coli)5 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal B cell physiology (MP:0002459)

  • abnormal humoral immune response (MP:0001800)

  • decreased B-1 B cell number (MP:0004978)

  • decreased IgA level (MP:0001807)

  • decreased IgG3 level (MP:0008498)
    • more 2 phenotypes
  • decreased immature B cell number (MP:0008215)

  • increased B cell number (MP:0005014)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Bst1 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 161, 3974-3983 (1998).a) The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR, Dr. Katsuhiko ISHIHARA (ishihara-im@med.kawasaki-m.ac.jp). b) RECIPIENT who wants to use the BIOLOGICAL RESOURCE for the purpose other than education and research in non-profit organization is requested to make a Material Transfer Agreement with Kawasaki medical school.
    DepositorKatsuhiko Ishihara (Kawasaki Medical School)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T.
    BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities.
    Nat Commun 12(1) 6767(2021) 34799586
    Wakabayashi T, Naito H, Suehiro JI, Lin Y, Kawaji H, Iba T, Kouno T, Ishikawa-Kato S, Furuno M, Takara K, Muramatsu F, Weizhen J, Kidoya H, Ishihara K, Hayashizaki Y, Nishida K, Yoder MC, Takakura N.
    CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.
    Cell Stem Cell 22(3) 384-397.e6(2018) 29429943