BRC No.RBRC02388
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Ly96<tm1Kmiy>
Former Common nameC57BL/6-MD-2 KO
H-2 Haplotype
ES Cell line
Background strain
Strain development
Strain description
Colony maintenance
ReferencesNat. Immunol. 3, 667-672 (2002) 12055629

Health Report

Examination Date / Room / Rack2012/02/20Room:3-CRack:G


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ly96lymphocyte antigen 961Ly96<tm1Kmiy>targeted mutation 1, Kensuke Miyake

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)1mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Ly96 genome DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature Immunology, 3, 667-672 (2002).
DepositorKensuke Miyake (The University of Tokyo)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Genotyping protocol -PCR-
Lab HP (Japanese)

BRC mice in Publications

Fang Q, Wang J, Zhang Y, Wang L, Li W, Han J, Huang W, Liang G, Wang Y.
Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis.
Biochim Biophys Acta Mol Basis Dis 1864(1) 252-262(2017) 28965884

Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, Zhang Y, Wu W, Liang G.
MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis.
Br. J. Pharmacol. 172(17) 4391-4405(2015) 26076332

Fang Q, Wang L, Yang D, Chen X, Shan X, Zhang Y, Lum H, Wang J, Zhong P, Liang G, Wang Y.
Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy.
J. Cell. Mol. Med. (2017) 28767204

Zhang Y, Wu B, Zhang H, Ge X, Ying S, Hu M, Li W, Huang Y, Wang L, Chen C, Shan X, Liang G.
Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease.
J. Cell. Mol. Med. (2017) 29077272

Wang L, Han J, Shan P, You S, Chen X, Jin Y, Wang J, Huang W, Wang Y, Liang G.
MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2.
Obesity (Silver Spring) 25(9) 1532-1539(2017) 28726347

Chen H, Song Z, Ying S, Yang X, Wu W, Tan Q, Ju X, Wu W, Zhang X, Qu J, Wang Y.
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway.
Toxicol. Lett. 282 109-120(2017) 29111459