RBRC02378

Information1

Image
BRC No.RBRC02378
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Nox1<tm1Cyn>
Former Common nameNox1 KO mouse, Nox1 knockout mouse
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Chihiro Yabe-Nishimura, Kuniharu Matsuno, Kazumi Iwata at Kyoto Prefectual University of Medicine in 2003.
Strain descriptionNox1 deficient mice. Nox1 gene is a member of the NADPH- dependent superoxide producing enzyme family, which is involved in the production of active oxygen in nonphagocytic cells on the intestine epithelium and vascular smooth muscle.
Colony maintenanceBackcross to C57BL/6 (Heterozygous or Hemizygote x C57BL/6CrSlc)
ReferencesCirculation, 112, 2677-2685 (2005) 16246966

Health Report

Examination Date / Room / Rack2009/02/23Room:3-CRack:G
2008/12/15Room:3-CRack:G
2008/10/20Room:3-CRack:G
2008/08/25Room:3-CRack:G
2008/06/23Room:3-CRack:G
2008/04/22Room:3-CRack:G
2008/04/21Room:3-CRack:G

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Nox1NADPH oxidaseXNox1<tm1Cyn>targeted mutation 1, Chihiro Yabe-Nishimura

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)Xmouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter, E. coli neomycin resistance gene, mouse Nox1genomic DNA
Research applicationCardiovascular Research
Metabolism Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Circulation, 112, 2677-2685 (2005).The BIOLOGICAL RESOURCE should not be utilized for the application of any patent for commercial purposes without an additional agreement with the DEPOSITOR. The RECIPIENT should not distribute the BIOLOGICAL RESOURCE including any progeny, unmodified derivatives, or any derivatives or genetically engineered modification if such derivative or modification is substantially based on and incorporates an essential element of the BIOLOGICAL RESOURCE to any other individual or entity without the DEPOSITOR's written consent. The RECIPIENT should inform results obtained using the BIOLOGICAL RESOURCE and discuss the authorship of the work with the DEPOSITOR prior to publication.
DepositorChihiro YABE (Kyoto Prefectural University of Medicine)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

No Data