BRC No.RBRC02374
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Cav3<tm1Ncnp>/177
Former Common namecav3-KO/B6(177), B6-Cav3 KO#177
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Toshikuni Sasaoka, National Institutes of Natural Sciences (National Institute of Neuroscience, National Center of Neurology and Psychiatry).
Strain descriptionCav3 (Caveolin 3) gene knockout mice. Cav3 is a muscle-specific form of the caveolin family proteins, which are small molecular weight proteins shown to be associated with the caveolar plasma membrane. Homozygous mutant mice show mid myopathic changes in muscle from 8 weeks ages. Viable and fertile. Line 177 (C57BL/6 background) (RBRC02374), Line 32 (mixed background) (RBRC02375), Line 142 (mixed background), Line 177 (mixed background) (RBRC02377).
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesHum Mol Genet. 2000 9(20):3047-54. 11115849

Health Report

Examination Date / Room / Rack2009/01/13Room:4-5Rack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Cav3caveolin 36Cav3<tm1Ncnp >targeted mutation 1, Tateki Kikuchi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)6mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E coli neo, mouse caveolin-3(Cav3) genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 9, 3047-3054 (2000).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorToshikuni Sasaoka (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data