RBRC02345

Information1

Image
BRC No.RBRC02345
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameFVB-Tg(NF2d39)27Gth
Former Common nameP0-Nf2delta2-3(#27)tg
H-2 Haplotype
ES Cell line
Background strainFVB
Appearancealbino [A/A B/B c/c D/D P/P]
Strain developmentDeveloped by Dr. Marco Giovannini, INSERM France in 1998. FVB background.
Strain descriptionThis transgenic mouse expresses mutant human neurofibromatosis 2 gene under the control of the Schwann cell-specific P0 gene promoter.
Colony maintenanceSibling Mating (Hemizygote x Wild-type)
ReferencesGenes Dev., 13, 978-986 (1999) 10215625

Health Report

Examination Date / Room / Rack2010/08/02Room:3-2Rack:D
2010/06/07Room:3-2Rack:D
2010/04/05Room:3-2Rack:D
2010/02/08Room:3-2Rack:D
2009/12/07Room:3-2Rack:D
2009/10/05Room:3-2Rack:D
2009/08/10Room:3-2Rack:D
2009/06/08Room:3-2Rack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Nf2neurofibromatosis 2UNNf2rat P0 promoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
HBB2rabbit beta-globin polyAUNHBB2

Information2

Donor DNArat P0 promoter, human NF2 cDNAs encoding isoform 1 of Sch-delta(39-121), rabbit beta-globin polyA
Research applicationCancer Research
Developmental Biology Research
Mouse Models for Human Disease
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 13, 978-986 (1999).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use.
RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention.
In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters.
DepositorMarco Giovannini (INSERM)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Truong K, Ahmad I, Jason Clark J, Seline A, Bertroche T, Mostaert B, Van Daele DJ, Hansen MR.
Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury.
Neuroscience (2018) 29408605