RBRC02342

Information1

Image
BRC No.RBRC02342
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Gak<tm1Noj>/+
Former Common nameGAK+/-, Cyclin G-associated kinase(GAK) heterozygous mouse
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2007.
Strain descriptionGak, cyclin G associated kinase gene knockout mice. Exons 2-4 of Gak gene were replaced with a pgk-neo cassette. Homozygous mutant mice die shortly after birth.
Colony maintenanceHeterozygote x Wild-type [or Crossing to C57BL/6JJcl]
ReferencesPLoS One, 6(10), e26034 (2011). 22022498

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Gakcyclin G associated kinase5Gak<tm1Noj>targeted mutation 1, Hiroshi Nojima

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)5mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse Gak genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo
Research applicationCancer Research
Cell Biology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Tabara H et al., "Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction." PLoS One 2011;6(10):e26034The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorHiroshi Nojima (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data