RBRC02339

Information1

Image
BRC No.RBRC02339
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy
Former Common namep210<bcr/abl> Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Honda and Hirai, University of Tokyo in 1998.
Strain descriptionThis transgenic strain expresses the p210 BCR/ABL1 gene. Tg mice show marked granulocyte hyperplasia and develop myeloproliferative disorders closely resembling human chronic myelogenous leukemia.
Colony maintenanceBackcross to C57BL/6 (Hemizygote x C57BL/6NCrlCrlj)
ReferencesBlood, 91, 2067-2075 (1998). 9490692
Blood. 2009 May 7;113(19):4702-10. 19234145
Cancer Sci. 2009 Jul;100(7):1219-26. 19432895
Oncogene. 2008 May 29;27(24):3465-74. 18193087

Health Report

Examination Date / Room / Rack2009/07/13Room:4-ARack:L
2009/05/19Room:4-ARack:L
2009/05/18Room:4-ARack:L
2009/03/16Room:4-ARack:L
2009/01/19Room:4-ARack:L
2008/11/17Room:4-ARack:L
2008/09/29Room:4-ARack:L
2008/07/14Room:4-ARack:L

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
BCR/ABL1p210 bcr/abl1 (human)UNBCR/ABL1mouse Tec

Gene symbolGene nameChr.Allele symbolAllele namePromoter
poly ASV40 polyA siganlUNpoly A

Information2

Donor DNAmouse Tec genomic DNA, human p210<bcr/abl> cDNA, SV40 virus poly A signal DNA
Research applicationCancer Research
Immunology and Inflammation Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHiroaki Honda (Tokyo Women's Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Sanchez-Sanchez B, Gutierrez-Herrero S, Lopez-Ruano G, Prieto-Bermejo R, Romo-Gonzalez M, Llanillo M, Pandiella A, Guerrero C, San Miguel JF, Sanchez-Guijo F, Del Canizo MC, Hernandez-Hernandez A.
NADPH oxidases as therapeutic targets in chronic myeloid leukemia.
Clin. Cancer Res. (2014) 24833663