Strain Data Sheet

RBRC02339

Strain Information

Image
BRC No.RBRC02339
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy
Former Common namep210<bcr/abl> Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Honda and Hirai, University of Tokyo in 1998.
Strain descriptionThis transgenic strain expresses the p210 BCR/ABL1 gene. Tg mice show marked granulocyte hyperplasia and develop myeloproliferative disorders closely resembling human chronic myelogenous leukemia.
Colony maintenanceBackcross to C57BL/6 (Hemizygote x C57BL/6NCrlCrlj)
References
Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias.
H Honda, H Oda, T Suzuki, T Takahashi, O N Witte, K Ozawa, T Ishikawa, Y Yazaki, H Hirai
Blood, 91, 2067-2075 (1998). 9490692

Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
T Mizuno, N Yamasaki, K Miyazaki, T Tazaki, R Koller, H Oda, Z-i Honda, M Ochi, L Wolff, H Honda
Oncogene. 2008 May 29;27(24):3465-74. 18193087

Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model.
Akiko Nagamachi, Norimasa Yamasaki, Kazuko Miyazaki, Hideaki Oda, Masaki Miyazaki, Zen-Ichiro Honda, Ryo Kominami, Toshiya Inaba, Hiroaki Honda
Cancer Sci. 2009 Jul;100(7):1219-26. 19432895

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.
Kazuko Miyazaki, Norimasa Yamasaki, Hideaki Oda, Takeshi Kuwata, Yohei Kanno, Masaki Miyazaki, Yukiko Komeno, Jiro Kitaura, Zen-ichiro Honda, Søren Warming, Nancy A Jenkins, Neal G Copeland, Toshio Kitamura, Takuro Nakamura, Hiroaki Honda
Blood. 2009 May 7;113(19):4702-10. 19234145

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
BCR/ABL1 p210 bcr/abl1 (human)UNBCR/ABL1 mouse Tec
poly A SV40 polyA siganlUNpoly A

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • enlarged spleen (MP:0000691)

  • increased acute lymphoblastic leukemia incidence (MP:0010336)

  • increased erythroid progenitor cell number (MP:0003135)

  • increased thymoma incidence (MP:0014127)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Tec genomic DNA, human p210<bcr/abl> cDNA, SV40 virus poly A signal DNA
    Research applicationCancer Research
    Immunology and Inflammation Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHiroaki Honda (Tokyo Women's Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Sánchez-Sánchez B, Gutiérrez-Herrero S, López-Ruano G, Prieto-Bermejo R, Romo-González M, Llanillo M, Pandiella A, Guerrero C, Miguel JF, Sánchez-Guijo F, Del Cañizo C, Hernández-Hernández A.
    NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.
    Clin Cancer Res 20(15) 4014-25(2014) 24833663