Strain Data Sheet

RBRC02334

Strain Information

Image
BRC No.RBRC02334
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.DBA/2J-Tg(NRGB1-TD4)
Former Common nameNRG1B1 Del Mutant, D2B6
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Miwako Ozaki, RIKEN Brain Science Institute in 2003.
Strain descriptionB6.B6D2-Tg(EF1A-GFP/Nrg1beta1)TD4. Neuregulin-1 (NRG-1) is a neurotrophic factor that is known to regulate the development of various tissues and/or the life/death of cells through activation of the ErbB family receptor tyrosine kinases, and implicated as a potential susceptibility gene for schizophrenia. This transgenic mice express a mutant NRG1beta1 (NRGB1) gene under the control of the EF1a-321 promoter. This strain is useful for investigating the function of the of NRG-1 gene.
Colony maintenanceCarrier x Noncarrier
References
Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner.
Ozaki M, Itoh K, Miyakawa Y, Kishida H, Hashikawa T
J. Neurochem., 91, 176-188 (2004) 15379898

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFPGreen Fluorescent Protein (Aequorea victoria)UNEF1a-321
  • schizophrenia 6(MedGEN)
    • Nrg1neuregulin 1 (mutant)UNNrg1EF1a-321
  • schizophrenia 6(MedGEN)
    • poly ASV40 polyA signalUNpoly A
  • schizophrenia 6(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal GABAergic neuron morphology(MP:0003245)

  • abnormal social/conspecific interaction behavior(MP:0002557)

  • decreased brain tyrosine 3-monooxygenase activity(MP:0020078)

  • decreased dopamine level(MP:0005643)

  • decreased locomotor activity(MP:0001402)
    • more 2 phenotypes
  • decreased prepulse inhibition(MP:0009142)

  • hyperactivity(MP:0001399)
    • Detailed phenotype data

    Ordering Information

    Donor DNACMV Promoter, Mouse Neuregulin-1beta cDNA, Jellyfish GFP cDNA, SV40 polyA Signal
    Research applicationFluorescent Proteins/lacZ System
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from Dr. Miwako OZAKI (Fax: 03-5272-1208).
    The RECIPIENT must contact Dr. Miwako OZAKI and RIKEN BSI in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorMiwako Ozaki (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data