BRC No.RBRC02334
SpeciesMus musculus
Strain nameB6.DBA/2J-Tg(NRGB1-TD4)
Former Common nameNRG1B1 Del Mutant, D2B6
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Miwako Ozaki, RIKEN Brain Science Institute in 2003.
Strain descriptionB6.B6D2-Tg(EF1A-GFP/Nrg1beta1)TD4. Neuregulin-1 (NRG-1) is a neurotrophic factor that is known to regulate the development of various tissues and/or the life/death of cells through activation of the ErbB family receptor tyrosine kinases, and implicated as a potential susceptibility gene for schizophrenia. This transgenic mice express a mutant NRG1beta1 (NRGB1) gene under the control of the EF1a-321 promoter. This strain is useful for investigating the function of the of NRG-1 gene.
Colony maintenanceCarrier x Noncarrier
ReferencesJ. Neurochem., 91, 176-188 (2004) 15379898

Health Report

Examination Date / Room / Rack2010/06/07Room:3-7Rack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Nrg1neuregulin 1 (mutant)UNNrg1EF1a-321

Gene symbolGene nameChr.Allele symbolAllele namePromoter
GFPGreen Fluorescent Protein (Jellyfish)UNEF1a-321

Gene symbolGene nameChr.Allele symbolAllele namePromoter
poly ASV40 polyA signalUNpoly A


Donor DNACMV Promoter, Mouse Neuregulin-1beta cDNA, Jellyfish GFP cDNA, SV40 polyA Signal
Research applicationFluorescent Proteins/lacZ System
Neurobiology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from Dr. Miwako OZAKI (Fax: 03-5272-1208).
The RECIPIENT must contact Dr. Miwako OZAKI and RIKEN BSI in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorMiwako Ozaki (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.

BRC mice in Publications

No Data