Strain Data Sheet
RBRC02330
Information1 | |
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| Image | |
| BRC No. | RBRC02330 |
| Type | Targeted Mutation Congenic |
| Species | Mus musculus |
| Strain name | NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk> |
| Former Common name | NODFcγRnull |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | albino [A/A c/c] |
| Strain development | Developed by Drs. Y. Inoue and T. Takai, Tohoku University in 2004. |
| Strain description | FcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background. |
| Colony maintenance | Sibling Mating (Homozygote x Homozygote)This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices. |
| References | Cell, 76(3):519-29 (1994). 8313472 J. Immunol., 179, 764-774 (2007). 17617565 Nature, 379, 346-349 (1996). 8552190 |
Health Report | |
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| Examination Date / Room / Rack | null |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>targeted mutation 1, Jeffrey V RavetchFce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Information2 | |
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| Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007). |
| Depositor | Toshiyuki Takai (Tohoku University) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H. Agonistic anti-CD40 induces thyrocyte proliferation and promotes thyroid autoimmunity by increasing CD40 expression on thyroid epithelial cells. J Immunol 190(8) 3928-38(2013) 23509363 |