RBRC02330
Information1 | |
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| Image | |
| BRC No. | RBRC02330 |
| Type | Targeted Mutation Congenic |
| Species | Mus musculus |
| Strain name | NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk> |
| Former Common name | NODFcγRnull |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | albino [A/A c/c] |
| Strain development | Developed by Drs. Y. Inoue and T. Takai, Tohoku University in 2004. |
| Strain description | FcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background. |
| Colony maintenance | Sibling Mating (Homozygote x Homozygote)This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices. |
| References | J. Immunol., 179, 764-774 (2007). 17617565 Cell, 76(3):519-29 (1994). 8313472 Nature, 379, 346-349 (1996). 8552190 |
Health Report | |
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| Examination Date / Room / Rack | 2020/03/09Room:2-検Rack:C 2020/01/06Room:2-検Rack:C 2019/11/11Room:2-検Rack:C 2011/04/18Room:3-ARack:I 2010/12/13Room:3-ARack:I 2010/10/18Room:3-ARack:I 2010/08/23Room:3-ARack:I 2010/06/21Room:3-ARack:I |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele namePromoter Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>targeted mutation 1, Jeffrey V Ravetch Gene symbolGene nameChr.Allele symbolAllele namePromoter Gene symbolGene nameChr.Allele symbolAllele namePromoter neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele namePromoter neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Information2 | |
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| Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007). |
| Depositor | Toshiyuki Takai (Tohoku University) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Genotyping protocol -PCR- |
BRC mice in Publications |
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Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H. Agonistic Anti-CD40 Induces Thyrocyte Proliferation and Promotes Thyroid Autoimmunity by Increasing CD40 Expression on Thyroid Epithelial Cells. J. Immunol. (2013) 23509363 |