RBRC02330

Information1

Image
BRC No.RBRC02330
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameNOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>
Former Common nameNODFcγRnull
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A c/c]
Strain developmentDeveloped by Drs. Y. Inoue and T. Takai, Tohoku University in 2004.
Strain descriptionFcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background.
Colony maintenanceSibling Mating (Homozygote x Homozygote)This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices.
ReferencesJ. Immunol., 179, 764-774 (2007). 17617565
Cell, 76(3):519-29 (1994). 8313472
Nature, 379, 346-349 (1996). 8552190

Health Report

Examination Date / Room / Rack2020/03/09Room:2-検Rack:C
2020/01/06Room:2-検Rack:C
2019/11/11Room:2-検Rack:C
2011/04/18Room:3-ARack:I
2010/12/13Room:3-ARack:I
2010/10/18Room:3-ARack:I
2010/08/23Room:3-ARack:I
2010/06/21Room:3-ARack:I

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide1Fcer1g<tm1Rav>targeted mutation 1, Jeffrey V Ravetch

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Fcgr2bFc receptor, IgG, low affinity IIb1Fcgr2b<tm1Ttk>targeted mutation 1, Toshiyuki Takai

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Fcer1g genomic DNA, mouse Fcgr2b genomic DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007).
DepositorToshiyuki Takai (Tohoku University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H.
Agonistic Anti-CD40 Induces Thyrocyte Proliferation and Promotes Thyroid Autoimmunity by Increasing CD40 Expression on Thyroid Epithelial Cells.
J. Immunol. (2013) 23509363