Strain Data Sheet

RBRC02329

Strain Information

Image
BRC No.RBRC02329
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameNOD.129S4(B6)-Fcgr2b<tm1Ttk>
Former Common nameNODIIB-/-
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainNOD/ShiJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.
Takai T, Ono M, Hikida M, Ohmori H, Ravetch J V
Nature, 379, 346-349 (1996). 8552190

Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice.
Inoue Y, Kaifu T, Sugahara-Tobinai A, Nakamura A, Miyazaki J, Takai T
J. Immunol., 179, 764-774 (2007). 17617565

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fcgr2bFc receptor, IgG, low affinity IIb1Fcgr2btargeted mutation 1, Toshiyuki Takai
neoneomycin resistance gene (E. coli)1

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal hypersensitivity reaction(MP:0002148)

  • abnormal mast cell physiology(MP:0002423)

  • abnormal seizure response to electrical stimulation(MP:0001650)

  • anemia(MP:0001577)

  • decreased body weight(MP:0001262)
    • more 30 phenotypes
  • decreased susceptibility to parasitic infection(MP:0005026)

  • dehydration(MP:0001429)

  • edema(MP:0001785)

  • enlarged lymph nodes(MP:0000702)

  • enlarged spleen(MP:0000691)

  • glomerulonephritis(MP:0002743)

  • hunched posture(MP:0001505)

  • hyperglycemia(MP:0001559)

  • increased IgA level(MP:0002495)

  • increased IgG level(MP:0002493)

  • increased IgG1 level(MP:0008499)

  • increased IgG2a level(MP:0008500)

  • increased IgG2b level(MP:0008501)

  • increased IgG3 level(MP:0008502)

  • increased IgM level(MP:0002494)

  • increased immunoglobulin level(MP:0002461)

  • increased inflammatory response(MP:0001846)

  • increased susceptibility to induced arthritis(MP:0003724)

  • increased susceptibility to type I hypersensitivity reaction(MP:0005596)

  • increased urine protein level(MP:0002962)

  • kidney inflammation(MP:0001859)

  • liver inflammation(MP:0001860)

  • lung inflammation(MP:0001861)

  • maximal tonic hindlimb extension seizures(MP:0002194)

  • no abnormal phenotype detected(MP:0002169)

  • pancreas inflammation(MP:0001869)

  • premature death(MP:0002083)

  • salivary gland inflammation(MP:0001870)

  • tonic-clonic seizures(MP:0003997)

  • vascular inflammation(MP:0001864)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo
    Research applicationDiabetes and Obesity Research
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 179, 764-774 (2007).
    DepositorToshiyuki Takai (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data