Strain Data Sheet

RBRC02304

Strain Information

Image
BRC No.RBRC02304
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-Kit<W-sh>(N18)
Former Common nameC57BL6-W<sh> N18
H-2 Haplotype
ES Cell line
Background strainC57BL/6NTac
Appearance
Strain development
Strain description
Colony maintenance
References
A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice.
M F Lyon, P H Glenister
Genet. Res., 39, 315-322 (1982). 7117838

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.
R Duttlinger, K Manova, T Y Chu, C Gyssler, A D Zelenetz, R F Bachvarova, P Besmer
Development, 118, 705-717 (1993). 7521281

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Michele A Grimbaldeston, Ching-Cheng Chen, Adrian M Piliponsky, Mindy Tsai, See-Ying Tam, Stephen J Galli
Am. J. Pathol., 167, 835-848 (2005). 16127161

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kit
MGI:96677		KIT proto-oncogene receptor tyrosine kinase5Kit<W-Sh>
MGI:1856265		sash
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal coat/hair pigmentation (MP:0002075)

  • abnormal definitive hematopoiesis (MP:0002123)

  • abnormal erythrocyte cell number (MP:0001586)

  • abnormal vascular permeability (MP:0001619)

  • absent coat pigmentation (MP:0005171)
    • more 8 phenotypes
  • decreased erythrocyte cell number (MP:0002875)

  • decreased mast cell degranulation (MP:0008765)

  • decreased mast cell number (MP:0000336)

  • decreased susceptibility to induced hypothermia (MP:0020523)

  • decreased susceptibility to type I hypersensitivity reaction (MP:0005597)

  • impaired behavioral response to xenobiotic (MP:0009747)

  • increased susceptibility to parasitic infection (MP:0005027)

  • variable body spotting (MP:0002940)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    Developmental Biology Research
    Immunology and Inflammation Research
    Reproductive Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genet. Res., 39, 315-322 (1982). Development, 118, 705-717 (1993). The RECIPIENT agrees to use of BIOLOGICAL RESOURCE only for publishing the research papers.
    DepositorShigeo Koyasu (Keio University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data