Strain Data Sheet

RBRC02301

Strain Information

Image
BRC No.RBRC02301
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.Cg-Pten<tm2Mak>
Former Common namePten-flox mouse (BALB/c)
H-2 Haplotype
ES Cell lineE14K [129P2/OlaHsd]
Background strainBALB/cAnNTac
Appearance
Strain development
Strain description
Colony maintenance
References
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Suzuki A, Yamaguchi M T, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi P S, Koyasu S, Penninger J M, Nakano T, Mak T W
Immunity, 14, 523-534 (2001) 11371355

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ptenphosphatase and tensin homolog19Ptentargeted mutation 2, Tak W Mak
  • Cowden disease(DisGeNET)

  • Cowden syndrome 1(MedGEN)

  • endometrial carcinoma(DisGeNET)
    • more 8 Diseases
  • familial meningioma(MedGEN)

  • glioma susceptibility 2(MedGEN)

  • head and neck squamous cell carcinoma(DisGeNET)

  • Lhermitte-Duclos disease(DisGeNET)

  • macrocephaly-autism syndrome(DisGeNET, MedGEN)

  • melanoma(DisGeNET)

  • prostate cancer(DisGeNET, MedGEN)

  • PTEN hamartoma tumor syndrome(DisGeNET)
    • loxPphage P1 loxP19loxP
  • Cowden disease(DisGeNET)

  • Cowden syndrome 1(MedGEN)

  • endometrial carcinoma(DisGeNET)
    • more 8 Diseases
  • familial meningioma(MedGEN)

  • glioma susceptibility 2(MedGEN)

  • head and neck squamous cell carcinoma(DisGeNET)

  • Lhermitte-Duclos disease(DisGeNET)

  • macrocephaly-autism syndrome(DisGeNET, MedGEN)

  • melanoma(DisGeNET)

  • prostate cancer(DisGeNET, MedGEN)

  • PTEN hamartoma tumor syndrome(DisGeNET)
    • loxPphage P1 loxP19loxP
  • Cowden disease(DisGeNET)

  • Cowden syndrome 1(MedGEN)

  • endometrial carcinoma(DisGeNET)
    • more 8 Diseases
  • familial meningioma(MedGEN)

  • glioma susceptibility 2(MedGEN)

  • head and neck squamous cell carcinoma(DisGeNET)

  • Lhermitte-Duclos disease(DisGeNET)

  • macrocephaly-autism syndrome(DisGeNET, MedGEN)

  • melanoma(DisGeNET)

  • prostate cancer(DisGeNET, MedGEN)

  • PTEN hamartoma tumor syndrome(DisGeNET)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • Mallory bodies(MP:0014045)

  • abnormal Purkinje cell morphology(MP:0000877)

  • abnormal astrocyte physiology(MP:0008916)

  • abnormal behavior(MP:0004924)

  • abnormal bone marrow cavity morphology(MP:0000065)
    • more 120 phenotypes
  • abnormal bone structure(MP:0003795)

  • abnormal cartilage morphology(MP:0000163)

  • abnormal cellular cholesterol metabolism(MP:0003191)

  • abnormal cerebellar Purkinje cell layer(MP:0000875)

  • abnormal cerebellar foliation(MP:0000857)

  • abnormal cerebellar granule cell morphology(MP:0004098)

  • abnormal cerebellar molecular layer(MP:0000889)

  • abnormal cerebellum external granule cell layer morphology(MP:0000872)

  • abnormal cerebellum morphology(MP:0000849)

  • abnormal chondrocyte morphology(MP:0000166)

  • abnormal dendrite morphology(MP:0008143)

  • abnormal dendritic spine morphology(MP:0009936)

  • abnormal dentate gyrus morphology(MP:0000812)

  • abnormal epiphyseal plate morphology(MP:0006395)

  • abnormal glomerular capillary morphology(MP:0011320)

  • abnormal heart morphology(MP:0000266)

  • abnormal hepatocyte morphology(MP:0000607)

  • abnormal hepatocyte physiology(MP:0010080)

  • abnormal hippocampal mossy fiber morphology(MP:0002761)

  • abnormal hippocampus CA1 region morphology(MP:0008263)

  • abnormal hippocampus morphology(MP:0000807)

  • abnormal hippocampus pyramidal cell layer(MP:0008284)

  • abnormal innervation(MP:0002184)

  • abnormal kidney collecting duct morphology(MP:0004754)

  • abnormal liver morphology(MP:0000598)

  • abnormal liver sinusoid morphology(MP:0008989)

  • abnormal long bone epiphysis morphology(MP:0000131)

  • abnormal long bone hypertrophic chondrocyte zone(MP:0000165)

  • abnormal long bone morphology(MP:0003723)

  • abnormal maternal nurturing(MP:0001386)

  • abnormal nervous system physiology(MP:0003633)

  • abnormal nest building behavior(MP:0001447)

  • abnormal renal glomerulus morphology(MP:0005325)

  • abnormal sexual interaction(MP:0002566)

  • abnormal social investigation(MP:0001360)

  • abnormal spike wave discharge(MP:0008840)

  • abnormal synapse morphology(MP:0009538)

  • abnormal synaptic vesicle number(MP:0004792)

  • abnormal tumor susceptibility(MP:0002166)

  • abnormal urinary bladder urothelium morphology(MP:0000540)

  • abnormal urothelium morphology(MP:0003630)

  • ataxia(MP:0001393)

  • decreased Purkinje cell number(MP:0000880)

  • decreased body size(MP:0001265)

  • decreased circulating insulin level(MP:0002727)

  • decreased fasting circulating glucose level(MP:0013278)

  • decreased hippocampus pyramidal cell number(MP:0009971)

  • digestive/alimentary phenotype(MP:0005381)

  • ectopic cartilage(MP:0003869)

  • ectopic cerebellar granule cells(MP:0002762)

  • ectopic neuron(MP:0011723)

  • ectopic ureteric bud(MP:0010980)

  • endometrium hyperplasia(MP:0009092)

  • enlarged heart(MP:0000274)

  • enlarged liver(MP:0000599)

  • epidermal hyperplasia(MP:0001222)

  • gliosis(MP:0002183)

  • hair follicle outer root sheath hyperplasia(MP:0010688)

  • hepatic steatosis(MP:0002628)

  • hindlimb paralysis(MP:0000755)

  • hippocampal neuron degeneration(MP:0000811)

  • hydrocephaly(MP:0001891)

  • hydronephrosis(MP:0000519)

  • hyperactivity(MP:0001399)

  • impaired branching involved in ureteric bud morphogenesis(MP:0004936)

  • impaired spatial learning(MP:0012307)

  • increased anxiety-related response(MP:0001363)

  • increased body length(MP:0001257)

  • increased bone mineral density(MP:0000062)

  • increased brain size(MP:0005238)

  • increased brain weight(MP:0002176)

  • increased circulating alanine transaminase level(MP:0002941)

  • increased circulating alkaline phosphatase level(MP:0002968)

  • increased circulating aspartate transaminase level(MP:0005343)

  • increased dentate gyrus size(MP:0012459)

  • increased hamartoma incidence(MP:0010306)

  • increased hepatocellular carcinoma incidence(MP:0003331)

  • increased hepatocyte number(MP:0014038)

  • increased hepatocyte proliferation(MP:0003893)

  • increased incidence of tumors by chemical induction(MP:0004499)

  • increased insulin sensitivity(MP:0002891)

  • increased liver adenoma incidence(MP:0003324)

  • increased liver cholesterol level(MP:0010027)

  • increased liver triglyceride level(MP:0009355)

  • increased liver weight(MP:0002981)

  • increased lymphoma incidence(MP:0012431)

  • increased mammary adenocarcinoma incidence(MP:0001883)

  • increased mammary gland tumor incidence in breeding females(MP:0012570)

  • increased mammary gland tumor incidence(MP:0010299)

  • increased metastatic potential(MP:0001272)

  • increased myocardial fiber size(MP:0004564)

  • increased myoepithelioma incidence(MP:0012043)

  • increased prostate gland adenocarcinoma incidence(MP:0009220)

  • increased prostate gland tumor incidence(MP:0010357)

  • increased prostate intraepithelial neoplasia incidence(MP:0009219)

  • increased saturated fatty acids level(MP:0005284)

  • increased spindle cell carcinoma incidence(MP:0010367)

  • increased startle reflex(MP:0001488)

  • increased stereotypic behavior(MP:0001409)

  • increased thigmotaxis(MP:0002797)

  • increased urinary bladder transitional cell carcinoma incidence(MP:0009551)

  • kyphosis(MP:0000160)

  • lethargy(MP:0005202)

  • liver fibrosis(MP:0003333)

  • liver inflammation(MP:0001860)

  • long tail(MP:0002758)

  • megacephaly(MP:0000434)

  • neoplasm(MP:0002006)

  • neuron hypertrophy(MP:0005603)

  • pale liver(MP:0000603)

  • postnatal lethality, complete penetrance(MP:0011085)

  • premature death(MP:0002083)

  • reduced sensorimotor gating(MP:0002635)

  • renal/urinary system phenotype(MP:0005367)

  • ruffled hair(MP:0000420)

  • seizures(MP:0002064)

  • sporadic seizures(MP:0000951)

  • thickened cerebral cortex(MP:0000789)

  • thin cerebellar granule layer(MP:0006099)

  • tonic-clonic seizures(MP:0003997)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Pten genomic DNA, phage P1 loxP
    Research applicationCancer Research
    Cell Biology Research
    Cre/loxP system
    General Purpose
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Tak W. Mak, Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca).
    DepositorShigeo Koyasu (Keio University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data