Strain Data Sheet

RBRC02272

Strain Information

Image
BRC No.RBRC02272
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Emx2<tm2(cre)Sia>/SiaRbrc
Former Common nameEmx2(Cre) (Acc. No. CDB0020K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium.
Kimura J, Suda Y, Kurokawa D, Hossain Z M, Nakamura M, Takahashi M, Hara A, Aizawa S
J. Neurosci., 25, 5097-5108 (2005). 15917450

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Emx2empty spiracles homeobox 219Emx2targeted mutation 2, Shinichi Aizawa
  • schizencephaly(MedGEN)
    • crePhage P1 Cre recombinase19cre
  • schizencephaly(MedGEN)
    • loxPphage P1 loxP19loxP
  • schizencephaly(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAP1 phage Cre, P1 phage loxP site, mouse Emx2 genomic DNA
    Research applicationCre/loxP system
    Neurobiology Research
    Specific Term and Conditions(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0020K and the BIOLOGICAL RESOURCE is requested (https://large.riken.jp/distribution/mutant-list.html). (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, The Journal of Neuroscience, 25, 5097-5108 (2005). (3) Please inform the DEVELOPER (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Moreno JA, Dudchenko O, Feigin CY, Mereby SA, Chen Z, Ramos R, Almet AA, Sen H, Brack BJ, Johnson MR, Li S, Wang W, Gaska JM, Ploss A, Weisz D, Omer AD, Yao W, Colaric Z, Kaur P, Leger JS, Nie Q, Mena A, Flanagan JP, Keller G, Sanger T, Ostrow B, Plikus MV, Kvon EZ, Aiden EL, Mallarino R.
    Emx2 underlies the development and evolution of marsupial gliding membranes.
    Nature 629(8010) 127-135(2024) 38658750