Strain Data Sheet

RBRC02270

Strain Information

Image
BRC No.RBRC02270
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameCB.Cg-Otx2<tm1Sia>/SiaRbrc
Former Common nameOtx2(-) (Acc. No. CDB0010K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Mouse Otx2 functions in the formation and patterning of rostral head.
Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S
Genes & Dev., 9, 2646-2658 (1995) 7590242

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Otx2orthodenticle homeobox 214Otx2targeted mutation 1, Shinichi Aizawa
  • pituitary hormone deficiency, combined, 6(MedGEN)

  • syndromic microphthalmia type 5(MedGEN)
    • neoneomycin resistance gene (E. coli)14mouse phosphoglycerate kinase promoter (PGK promoter)
  • pituitary hormone deficiency, combined, 6(MedGEN)

  • syndromic microphthalmia type 5(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Meckel's cartilage morphology(MP:0005587)

  • abnormal adenohypophysis morphology(MP:0004163)

  • abnormal alisphenoid bone morphology(MP:0003235)

  • abnormal anterior eye segment morphology(MP:0005193)

  • abnormal basisphenoid bone morphology(MP:0000106)
    • more 75 phenotypes
  • abnormal brain development(MP:0000913)

  • abnormal ciliary ganglion morphology(MP:0004990)

  • abnormal cornea morphology(MP:0001312)

  • abnormal craniofacial morphology(MP:0000428)

  • abnormal cranium morphology(MP:0000438)

  • abnormal embryonic neuroepithelium morphology(MP:0004261)

  • abnormal extraocular muscle morphology(MP:0005247)

  • abnormal eye distance/ position(MP:0001299)

  • abnormal eye morphology(MP:0002092)

  • abnormal eyelid morphology(MP:0001340)

  • abnormal foregut morphology(MP:0000474)

  • abnormal gastrulation(MP:0001695)

  • abnormal head morphology(MP:0000432)

  • abnormal heart morphology(MP:0000266)

  • abnormal hindbrain morphology(MP:0000841)

  • abnormal incus morphology(MP:0005106)

  • abnormal inferior colliculus morphology(MP:0000776)

  • abnormal malleus morphology(MP:0000029)

  • abnormal mandible morphology(MP:0000458)

  • abnormal mesendoderm development(MP:0009266)

  • abnormal midbrain-hindbrain boundary morphology(MP:0012132)

  • abnormal nasal capsule morphology(MP:0004726)

  • abnormal nasal cavity morphology(MP:0002237)

  • abnormal nasal septum morphology(MP:0002239)

  • abnormal nasopharynx morphology(MP:0002251)

  • abnormal nose morphology(MP:0002233)

  • abnormal oculomotor nerve morphology(MP:0001061)

  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal olfactory epithelium morphology(MP:0008789)

  • abnormal orbitosphenoid bone morphology(MP:0004457)

  • abnormal palate morphology(MP:0003755)

  • abnormal presphenoid bone morphology(MP:0004448)

  • abnormal pterygoid bone morphology(MP:0004453)

  • abnormal retina layer morphology(MP:0003727)

  • abnormal sclera morphology(MP:0002698)

  • abnormal snout morphology(MP:0000443)

  • abnormal temporal bone morphology(MP:0005272)

  • abnormal temporal bone tympanic part morphology(MP:0030320)

  • abnormal third ventricle morphology(MP:0000826)

  • abnormal trigeminal V mesencephalic nucleus morphology(MP:0000906)

  • abnormal trigeminal nerve morphology(MP:0001065)

  • abnormal trochlear nerve morphology(MP:0001063)

  • abnormal vomeronasal organ morphology(MP:0002243)

  • absent choroid plexus(MP:0008934)

  • absent cornea(MP:0012247)

  • absent forebrain(MP:0012136)

  • absent foregut(MP:0012083)

  • absent heart(MP:0011388)

  • absent mandible(MP:0000087)

  • absent mandibular coronoid process(MP:0004912)

  • absent metencephalon(MP:0012516)

  • absent midbrain(MP:0012087)

  • absent nasal capsule(MP:0008384)

  • absent nasal septum(MP:0004872)

  • absent olfactory bulb(MP:0003451)

  • absent orbitosphenoid bone(MP:0030102)

  • absent tongue(MP:0009905)

  • absent vomeronasal organ(MP:0013595)

  • acephaly(MP:0009579)

  • aniridia(MP:0005261)

  • anophthalmia(MP:0001293)

  • aphakia(MP:0003078)

  • basisphenoid bone foramen(MP:0004463)

  • decreased embryonic neuroepithelium thickness(MP:0012703)

  • embryonic growth arrest(MP:0001730)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • holoprosencephaly(MP:0005157)

  • micrognathia(MP:0002639)

  • microphthalmia(MP:0001297)

  • neonatal lethality, incomplete penetrance(MP:0011088)

  • premature death(MP:0002083)

  • retina pigment epithelium hyperplasia(MP:0005549)

  • rostral body truncation(MP:0012157)

  • short snout(MP:0000445)

  • small cranium(MP:0005352)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neo, mouse phosphoglycerate kinase promoter (PGK promoter), mouse Otx2 genomic DNA
    Research applicationDevelopmental Biology Research
    Specific Term and Conditions(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0010K and the BIOLOGICAL RESOURCE is requested (https://large.riken.jp/distribution/mutant-list.html). (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Genes & Dev. 9, 2646-2658 (1995). (3) Please inform the DEVELOPER (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data