RBRC02269

Information1

Image
BRC No.RBRC02269
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Sgcg<tm1Oza>
Former Common nameGSG-KO (C57BL/6J), B6-Sgcg KO
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Toshikuni Sasaoka, National Institutes of Natural Sciences (National Institute of Neuroscience, National Center of Neurology and Psychiatry).
Strain descriptionGamma-sarcoglycan (Sgcg) gene knockout mice. Sgcg is a transmembrane, dystrophin-associated protein expressed in skeletal and cardiac muscle. Homozygous mutant mice show skeletal and cardiac muscle degeneration.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesNeuromuscul Disord. 2003 13(3):193-206. 12609501

Health Report

Examination Date / Room / Rack2009/11/09Room:4-5Rack:C
2009/09/07Room:4-5Rack:C
2009/07/06Room:4-5Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)14Sgcg<tm1Oza>targeted mutation 1, Eijiro Ozawa

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)14

Information2

Donor DNAE coli neo, mouse gamma-sarcoglycan (GSG) genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter)
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuromuscul. Disord., 13, 193-206 (2003).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorToshikuni Sasaoka (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data