Strain Data Sheet

RBRC02267

Strain Information

Image
BRC No.RBRC02267
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(HRAS)2Mok
Former Common namehuman H-ras Tg, B6-HRAS Tg#2
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences (School of Medicine, Tokai University).
Strain descriptionHuman HRAS gene trainsgenic mice.
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
References
Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M
Oncogene, 5, 1195-1200 (1990). 2202951

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HRASHarvey rat sarcoma virus oncogene (human)UNHRAStransgene insertion 2

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal hypaxial muscle morphology(MP:0003358)

  • abnormal pectoral muscle morphology(MP:0003346)

  • abnormal skeletal muscle fiber morphology(MP:0003084)

  • abnormal skeletal muscle morphology(MP:0000759)

  • abnormal tumor morphology(MP:0003448)
    • more 16 phenotypes
  • centrally nucleated skeletal muscle fibers(MP:0009404)

  • decreased body weight(MP:0001262)

  • decreased survivor rate(MP:0008770)

  • increased adenocarcinoma incidence(MP:0009308)

  • increased classified tumor incidence(MP:0010273)

  • increased incidence of tumors by chemical induction(MP:0004499)

  • increased lung adenocarcinoma incidence(MP:0002027)

  • increased lymphoma incidence(MP:0012431)

  • increased sarcoma incidence(MP:0002032)

  • increased skin papilloma incidence(MP:0002051)

  • increased tumor incidence(MP:0002020)

  • increased variability of skeletal muscle fiber size(MP:0009403)

  • neoplasm(MP:0002006)

  • skeletal muscle fiber degeneration(MP:0009412)

  • skeletal muscle fiber necrosis(MP:0009414)

  • skeletal muscle interstitial fibrosis(MP:0003851)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman rasH2 oncogene genomic DNA
    Research applicationCancer Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 5, 1195-1200 (1990).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data