Strain Data Sheet

RBRC02220

Strain Information

Image
BRC No.RBRC02220
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Mafb<tm(GFP)UTR>
Former Common name
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
MafB is essential for renal development and F4/80 expression in macrophages.
Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves D R, Engel J D, Yamamoto M, Takahashi S
Mol. Cell Biol., 26, 5715-5727 (2006). 16847325

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFPGreen Fluorescent Protein (Aequorea victoria)2
  • Duane retraction syndrome 3 with or without deafness(MedGEN)

  • multicentric carpo-tarsal osteolysis with or without nephropathy(MedGEN)
    • MafbMAF bZIP transcription factor B2Mafbtargeted mutation
  • Duane retraction syndrome 3 with or without deafness(MedGEN)

  • multicentric carpo-tarsal osteolysis with or without nephropathy(MedGEN)
    • loxPphage P1 loxP2loxP
  • Duane retraction syndrome 3 with or without deafness(MedGEN)

  • multicentric carpo-tarsal osteolysis with or without nephropathy(MedGEN)
    • loxPphage P1 loxP2loxP
  • Duane retraction syndrome 3 with or without deafness(MedGEN)

  • multicentric carpo-tarsal osteolysis with or without nephropathy(MedGEN)
    • neoneomycin resistance gene (E. coli)2herpes simplex virus thymidine kinase promoter (HSV tk promoter)
  • Duane retraction syndrome 3 with or without deafness(MedGEN)

  • multicentric carpo-tarsal osteolysis with or without nephropathy(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal kidney development(MP:0000527)

  • abnormal podocyte foot process morphology(MP:0008059)

  • abnormal renal/urinary system morphology(MP:0000516)

  • abnormal seminiferous tubule epithelium morphology(MP:0011750)

  • absent urinary bladder(MP:0009252)
    • more 9 phenotypes
  • decreased macrophage cell number(MP:0003884)

  • increased circulating creatinine level(MP:0005553)

  • increased kidney apoptosis(MP:0011368)

  • increased podocyte apoptosis(MP:0011282)

  • increased renal glomerulus apoptosis(MP:0011369)

  • kidney atrophy(MP:0004970)

  • kidney hemorrhage(MP:0000533)

  • renal glomerulus cyst(MP:0011682)

  • renal tubular necrosis(MP:0004154)
    • Detailed phenotype data

    Ordering Information

    Donor DNAjellyfish GFP cDNA, P1 phage loxP sites, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Pgk poly A additional signal, mouse MafB gene
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    General Purpose
    Sensorineural Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 26, 5715-5727 (2006).
    DepositorSatoru Takahashi (University of Tsukuba)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data