Strain Data Sheet

RBRC02219

Strain Information

Image
BRC No.RBRC02219
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Use1<tm1.1Aha>
Former Common namep31flox, 11, B6;129-Use1<tm1.1>
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.
Uemura T, Sato T, Aoki T, Yamamoto A, Okada T, Hirai R, Harada R, Mori K, Tagaya M, Harada A
Mol. Cell. Biol., 29(7):1869-1881 (2009). 19188447

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frtyeast FRT (flippase recombination target) site8Frt
Use1unconventional SNARE in the ER 1 homolog (S. cerevisiae)8Use1targeted mutation 1.1, Akihiko Harada
loxPphage P1 loxP8loxP
loxPphage P1 loxP8loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal brain ventricle morphology(MP:0000822)

  • abnormal cell physiology(MP:0005621)

  • abnormal endoplasmic reticulum morphology(MP:0009378)

  • abnormal gait(MP:0001406)

  • abnormal nervous system physiology(MP:0003633)
    • more 6 phenotypes
  • abnormal neuron morphology(MP:0002882)

  • ataxia(MP:0001393)

  • decreased Purkinje cell number(MP:0000880)

  • increased apoptosis(MP:0006042)

  • neonatal lethality(MP:0002058)

  • thin cerebral cortex(MP:0006254)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP, yeast FRT
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 29(7):1869-81. (2009).The RECIPIENT of BIOLOGICAL resource shall obtain a prior written consent on use of it from the DEPOSITOR Dr. Mitsuo Tagaya, Tokyo University of Pharmacy and Life Sciences. The RECIPIENT must send a copy of the APPROVAL FORM approved by Dr. Mitsuo Tagaya to Dr. Akihiko Harada, Gunma University. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Within a period of TWO years after the first paper concerning the analysis of the BIOLOGICAL RESOURCE is published, the RECIPIENT agree to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorDrs. Mitsuo Tagaya and Akihiro Harada (Tokyo University of Pharmacy and Life Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data