RBRC02217

Information1

Image
BRC No.RBRC02217
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameSTOCK Tg(MoMuLV/RET-MEN2A)121Mat
Former Common nameTg2A-121
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack (a/a B/? C/C)
brown (a/a b/b C/C)
Strain developmentDeveloped by Dr. K. Kawai, Nagoya University School of Medicine in 1999. C57BL/6 and BALB/c mixed background.
Strain descriptionThis transgenic mouse was generated by introducing RET with a MEN2A (cysteine 634 arginine) mutation fused to Moloney murine leukemia virus long terminal repeat. The heterozygous mice develop thyroid C-cell hyperplasia or medullary carcinoma.
Colony maintenanceSibling Mating (Heterozygote x Wild-type)
ReferencesCancer Research, 60, 5254-5260 (2000). 11016655

Health Report

Examination Date / Room / Rack2014/10/06Room:3-5Rack:B
2014/08/04Room:3-5Rack:B
2014/06/02Room:3-5Rack:B
2014/04/07Room:3-5Rack:B
2014/02/03Room:3-5Rack:B
2013/12/02Room:3-5Rack:B
2013/10/07Room:3-5Rack:B
2013/08/05Room:3-5Rack:B

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
RETrecombinant RET proto-oncogene (human)UNRETMoMuLV LTR

Gene symbolGene nameChr.Allele symbolAllele namePromoter
polyArat insulinUNpolyA

Information2

Donor DNAhuman c-Ret cDNA (MEN2A-type mutant), MoMuLV LTR, rat insulin poly A, SV40 poly(A) signal
Research applicationCancer Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cancer Researh, 60, 5254-5260 (2000).
DepositorMasahide Takahashi (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data