Strain Data Sheet

RBRC02187

Strain Information

Image
BRC No.RBRC02187
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSmt
Former Common name
H-2 Haplotype
ES Cell line
Background strainSmt (C57BL/6, DDK, CBA)
Appearancealbino [A/A B/B c/c]
agouti [A/A B/B C/c]
Strain developmentDeveloped by Drs. Noboru Wakasugi and Hasbaira Bolor at Nagoya University in 1997-2007.
Strain descriptionSpontaneous mutant strain having small testes. Mixed background (C57BL/6=10.9%, DDK=76.6%, CBA=12.5%)
Colony maintenanceSibling Mating (Homozyous, Heterozygous female x Heterozygous male, albino x agouti)
References
Arrest of spermatogenesis at the early meiotic stage in the small testis mutant (Smt) mice.
Hasbaira Bolor, Wei Dong Zhao, Akira Ishikawa, Noboru Wakasugi
Exp. Anim., 54, 327-337 (2005). 16093646

Detection of quantitative trait loci causing abnormal spermatogenesis and reduced testis weight in the small testis (Smt) mutant mouse.
Hasbaira Bolor, Noboru Wakasugi, Wei Dong Zhao, Akira Ishikawa
Exp. Anim., 55, 97-108 (2006). 16651692

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
smt small testissmt

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal male meiosis (MP:0005169)

  • abnormal sperm number (MP:0002673)

  • abnormal spermatid morphology (MP:0006380)

  • abnormal spermatocyte morphology (MP:0006379)

  • abnormal spermatogenesis (MP:0001156)
    • more 3 phenotypes
  • failure of zygotic cell division (MP:0003406)

  • seminiferous tubule degeneration (MP:0001154)

  • small testis (MP:0001147)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationReproductive Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Exp. Anim., 54, 327-337 (2005).
    DepositorTakao Namikawa (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data