BRC No.RBRC02149
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ctnnbip1<tm1Taki>
Former Common nameICAT Knock-out mouse
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Akiyama at Institute for Molecular and Cellular Bioscviences, University of Tokyo in 2001.
Strain descriptionICAT, Inhibitor of beta-catenin and Tcell factor is an 81 amino acid protein that interferes with the interaction between beta-catenin and TCF. The ICAT gene ubiquitously expressed in embryo, and brain, heart, liver and skeletal muscle in adult of mouse. ICAT homozygous mutant mice show malformation of the forebrain and craniofacial bones and lack kidney, and dead within 1 day after birth.
Colony maintenanceHeterozygote x C57BL/6 [C57BL/6NJcl]
ReferencesProc. Natl. Acad. Sci. USA, 101, 8017-8021 (2004). 15148409

Health Report

Examination Date / Room / Rack2007/08/20Room:3-CRack:E


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Ctnnbip1catenin beta interacting protein 14Ctnnbip1<tm1Taki>targeted mutation 1, Tetsu Akiyama

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAmouse phosphoglycerate kinase-1 promoter, E. coli neo, mouse ICAT genomic DNA
Research applicationDevelopmental Biology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 101, 8017-8021 (2004).The RECIPIENT of BIOLOGICAL RESOURCE shall inform the DEPOSITOR about the research project using the BIOLOGICAL RESOURCE, and agrees to include the DEPOSITOR as a co-author in any publications resulted by the used of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. After the two years' period the RECIPIENT shall acknowledge to the DEPOSITOR in any publications resulted by the use of the BIOLOGICAL RESOURCE.
DepositorTetsu Akiyama (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

No Data