BRC No.RBRC02105
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Spen<tm2.1>/HonRbrc
Former Common nameMint floxed mouse
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Strain developmentDeveloped by Drs. Diasuke Yabe and Tasuku Honjo at Kyoto University in 2004.
Strain descriptionB6.Cg-Spen<tm2.1>. Mint, Msx2 interacting nuclear target protein which is a suppressor factor of a Notch/RBP-J signaling pathway, plays a role in fate determination. This strain has a loxP-flanked Mint allele. Conditional Mint deficient mice can be generated by crossing with tissue-specific Cre mice. This strain is useful for elucidating the mechanism of Notch/RBP-J signaling pathway in mammals.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
ReferencesGenesis 45(5):300-306 (2007). 17457934

Health Report

Examination Date / Room / Rack2009/07/06Room:4-3Rack:B


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
SpenSPEN homolog, transcriptional regulator (Drosophila)4Spen<tm2.1Hon>targeted mutation 2.1, Tasuku Honjo

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP4loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP4loxP


Donor DNAphage P1 loxP sites, mouse Mint genomic DNA
Research applicationCre/loxP system
Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Yabe et al., Genesis 45(5):300-306 (2007).
3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
DepositorTasuku Honjo (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Honjo Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data