Strain Data Sheet

RBRC02104

Strain Information

Image
BRC No.RBRC02104
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Spen<tm2.1Hon> Rbpj<tm1Hon>/HonRbrc
Former Common nameMint/RBP-J floxed mouse
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.
Yabe D, Fukuda H, Aoki M, Yamada S, Takebayashi S, Shinkura R, Yamamoto N, Honjo T
Genesis 45(5):300-306 (2007). 17457934

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Spenspen family transcription repressor4Spentargeted mutation 2.1, Tasuku Honjo
  • Adams-Oliver syndrome 3(MedGEN)
    • loxPphage P1 loxP4loxP
  • Adams-Oliver syndrome 3(MedGEN)
    • loxPphage P1 loxP4loxP
  • Adams-Oliver syndrome 3(MedGEN)
    • Rbpjrecombination signal binding protein for immunoglobulin kappa J region5Rbpjtargeted mutation 1, Tasuku Honjo
  • Adams-Oliver syndrome 3(MedGEN)
    • loxPphage P1 loxP5loxP
  • Adams-Oliver syndrome 3(MedGEN)
    • loxPphage P1 loxP5loxP
  • Adams-Oliver syndrome 3(MedGEN)
    • neoneomycin resistance gene (E. coli)5mouse phosphoglycerate kinase promoter (PGK promoter)
  • Adams-Oliver syndrome 3(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • immune system phenotype(MP:0005387)

  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Spen genomic DNA, mouse Rbpj genomic DNA
    Research applicationCre/loxP system
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Yabe et al., Genesis 45(5):300-306 (2007).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data