RBRC01958

Information1

Image
BRC No.RBRC01958
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ahnak<tm1Jtak>
Former Common nameAhnaktm1Tak
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Junji Takeda at Osaka University in 2001.
Strain descriptionAHNAK/Desmoyokin is a ubiquitous protein expressed in a variety of cell type, distributes mainly on the cell membranes, suggesting that this gene plays a role in cell-cell adhesion. Homozygous mutant mice are viable and fertile, and show no overt abnormalities.
Colony maintenanceBackcross to C57BL/6J
ReferencesJ. Invest. Dermatol., 123, 700-707 (2004). 15373775

Health Report

Examination Date / Room / Rack2008/11/17Room:4-ARack:C
2008/09/29Room:4-ARack:C
2008/07/14Room:4-ARack:C
2008/05/20Room:4-ARack:C
2008/05/19Room:4-ARack:C
2008/03/17Room:4-ARack:C
2008/01/14Room:4-ARack:C
2007/11/12Room:4-ARack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
AhnakAHNAK nucleoprotein (demoyokin)19Ahnak<tm1Jtak>targeted mutation 1, Junji Takeda

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP19loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP19loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)19

Information2

Donor DNAmouse Ahnak genomic DNA, mouse PGK promoter, E.coli neo, phage P1 loxP
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Invest Dermatol, 123, 700-707 (2004).RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University.
DepositorJunji Takeda (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Takeda Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

von Boxberg Y, Soares S, F r ol S, Fodil R, Bartolami S, Taxi J, Tricaud N, Nothias F.
Giant scaffolding protein AHNAK1 interacts with beta-dystroglycan and controls motility and mechanical properties of schwann cells.
Glia (2014) 24796807