Strain Data Sheet

RBRC01934

Strain Information

Image
BRC No.RBRC01934
TypeCongenic
SpeciesMus musculus
Strain nameC3.NSY-(D11Mit74-D11Mit229)
Former Common nameC3H.NSY-Nidd1n R1 congenic
H-2 Haplotype
ES Cell line
Background strainC3H/HeNCrlCrlj
Appearance
Strain developmentDeveloped by Hiroshi Ikegami, Graduate School of Medicine, Osaka University in 2005.
Strain descriptionThis congenic strain was established by the integration of a MSY-derived genomic region from chromosome 11 into a C3H/HeNCrj genetic background. The integrated genomic region involves a QTL, Nidd1n, for glucose tolerance, which was identified using genetic mapping in the NSY strain (a mouse model for type 2 diabetes) and C3H as a control. This congenic strain (Nidd1nR1) was produced by backcrossing of the region between D11Mit74 to D11Mit229 of NSY onto the C3H.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
References
Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11.
Babaya N, Ikegami H, Fujisawa T, Nojima K, Itoi-Babaya M, Inoue K, Ohno T, Shibata M, Ogihara T
Biochem. Biophys. Res. Commun., 328, 158-164 (2005). 15670764

Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait.
Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Yamato E, Shibata M, Ogihara T
Diabetes, 48, 1168-1174 (1999). 10331425

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • hyperglycemia(MP:0001559)

  • impaired glucose tolerance(MP:0005293)

  • increased circulating glucose level(MP:0005559)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorHiroshi Ikegami (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Ohno T, Maegawa T, Katoh H, Miyasaka Y, Suzuki M, Kobayashi M, Horio F.
    A new missense mutation in the paired domain of the mouse Pax3 gene.
    Exp Anim 66(3) 245-250(2017) 28381738