RBRC01924

Information1

Image
BRC No.RBRC01924
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129(Cg)-Zeb2<tm1.1Yhi>
Former Common nameSIP1 flox (ex7), B6;129-Zfhx1b<tm1.1Yhi>
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Yujiro Higashi, Osaka University in 2002.
Strain descriptionSmad-interacting protein 1, SIP1 is a member of the ZFHX1 family of two-handed zinc finger nuclear factors that are associated with epithelial mesenchymal transitions (EMT) during development. Conditional SIP1 deficient mice can be generated bycrossing with tissue specific Cre transgenic mice.
Colony maintenanceBackcross to C57BL/6Cr
ReferencesGenesis, 32, 82-84 (2002). 11857784

Health Report

Examination Date / Room / Rack2012/11/05Room:2-3Rack:C
2012/09/03Room:2-3Rack:C
2012/07/02Room:2-3Rack:C
2012/05/07Room:2-3Rack:C
2012/03/05Room:2-3Rack:C
2010/02/22Room:3-CRack:H
2009/12/14Room:3-CRack:H
2009/10/19Room:3-CRack:H

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Zfhx1bzinc finger homeobox 1b2Zfhx1b<tm1.1Yhi>targeted mutation 1.2, Yujiro Higashi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP2loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP2loxP

Information2

Donor DNAphage P1 loxP sites, mouse Zfhx1b genomic DNA
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 32, 82-84 (2002).The RECIPIENT should consult with the DEPOSITOR in the case of application for any patents or commercial use with the results derived from the use of the BIOLOGICAL RESOURCE. The RECIPIENT should consult with the DEPOSITOR on the authorship upon publications of the results obtained from the use of the BIOLOGICAL RESOURCE. The authorship should be considered in accordance to generally accepted practices and decided through agreement between the RECIPIENT and the DEPOSITOR/DEVELOPER.
DepositorYujiro Higashi (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data