Strain Data Sheet
RBRC01908
Information1 | |
|---|---|
| Image |  |
| BRC No. | RBRC01908 |
| Type | Transgene Congenic |
| Species | Mus musculus |
| Strain name | B6.Cg-Tg(Mt1-Il5)6Ato |
| Former Common name | IL-5 Transgenic mice |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | C57BL/6 |
| Appearance | |
| Strain development | Generated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine). |
| Strain description | Mt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter. |
| Colony maintenance | Carrier x Carrier (Homozygous x Homozygote) Tg mice show no obvious abnormality. |
| References | J. Exp. Med., 173, 429-437 (1991). 1988543 |
Health Report | |
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| Examination Date / Room / Rack | 2021/12/14Room:3-3Rack:C 2021/09/13Room:3-3Rack:C 2021/06/14Room:3-3Rack:C 2021/03/29Room:3-3Rack:C 2021/01/05Room:3-3Rack:C |
Gene | |
|---|---|
| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBB2rabbit beta-globin splice donorUNHBB2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBB2rabbit beta-globin splice acceptorUNHBB2 |
Information2 | |
|---|---|
| Donor DNA | mouse metallothionein promoter, rabbit beta-globin SD, rabbit beta-globin SA, mouse IL5 cDNA, rabbit beta-globin polyA, SV40 polyadenylation site |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 173, 429-437 (1991). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Kiyoshi Takatsu (The University of Tokyo) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Genotyping protocol -PCR- Necessary documents for ordering: |
BRC mice in Publications |
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Aihara N, Kamiie J, Yamada M, Shirota K. The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. Am J Pathol 185(1) 172-84(2015) 25452118 Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J 28(9) 4036-43(2014) 24891522 |