RBRC01908

Information1

Image
BRC No.RBRC01908
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Mt1-Il5)6Ato
Former Common nameIL-5 Transgenic mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearance
Strain developmentGenerated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine).
Strain descriptionMt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter.
Colony maintenanceCarrier x Carrier (Homozygous x Homozygote) Tg mice show no obvious abnormality.
ReferencesJ. Exp. Med., 173, 429-437 (1991). 1988543

Health Report

Examination Date / Room / Rack2010/09/06Room:4-2Rack:C
2010/07/05Room:4-2Rack:C
2010/05/10Room:4-2Rack:C
2010/03/08Room:4-2Rack:C
2009/11/09Room:4-2Rack:C
2009/09/07Room:4-2Rack:C
2009/07/06Room:4-2Rack:C
2009/05/12Room:4-2Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Il5interleukin 5UNIl5metallothionein 1

Gene symbolGene nameChr.Allele symbolAllele namePromoter
HBB2rabbit beta-globin splice acceptorUNHBB2

Gene symbolGene nameChr.Allele symbolAllele namePromoter
HBB2rabbit beta-globin splice donorUNHBB2

Information2

Donor DNAmouse metallothionein promoter, rabbit beta-globin SD, rabbit beta-globin SA, mouse IL5 cDNA, rabbit beta-globin polyA, SV40 polyadenylation site
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 173, 429-437 (1991).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorKiyoshi Takatsu (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Aihara N, Kamiie J, Yamada M, Shirota K.
The Development of Mixed Cryoglobulinemia in Capillaria hepatica-Infected Mice Is Associated with the Capillaria Antigen-Induced Selective Proliferation of Splenic B-1a Cells in Response to Interleukin-5 Stimulation.
Am. J. Pathol. (2014) 25452118

Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M.
Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.
FASEB J. (2014) 24891522