RBRC01908
Information1 | |
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| Image |  |
| BRC No. | RBRC01908 |
| Type | Transgene Congenic |
| Species | Mus musculus |
| Strain name | B6.Cg-Tg(Mt1-Il5)6Ato |
| Former Common name | IL-5 Transgenic mice |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | C57BL/6 |
| Appearance | |
| Strain development | Generated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine). |
| Strain description | Mt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter. |
| Colony maintenance | Carrier x Carrier (Homozygous x Homozygote) Tg mice show no obvious abnormality. |
| References | J. Exp. Med., 173, 429-437 (1991). 1988543 |
Health Report | |
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| Examination Date / Room / Rack | 2010/09/06Room:4-2Rack:C 2010/07/05Room:4-2Rack:C 2010/05/10Room:4-2Rack:C 2010/03/08Room:4-2Rack:C 2009/11/09Room:4-2Rack:C 2009/09/07Room:4-2Rack:C 2009/07/06Room:4-2Rack:C 2009/05/12Room:4-2Rack:C |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele namePromoter Gene symbolGene nameChr.Allele symbolAllele namePromoter HBB2rabbit beta-globin splice acceptorUNHBB2 Gene symbolGene nameChr.Allele symbolAllele namePromoter HBB2rabbit beta-globin splice donorUNHBB2 |
Information2 | |
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| Donor DNA | mouse metallothionein promoter, rabbit beta-globin SD, rabbit beta-globin SA, mouse IL5 cDNA, rabbit beta-globin polyA, SV40 polyadenylation site |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 173, 429-437 (1991).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Kiyoshi Takatsu (The University of Tokyo) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Genotyping protocol -PCR- |
BRC mice in Publications |
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Aihara N, Kamiie J, Yamada M, Shirota K. The Development of Mixed Cryoglobulinemia in Capillaria hepatica-Infected Mice Is Associated with the Capillaria Antigen-Induced Selective Proliferation of Splenic B-1a Cells in Response to Interleukin-5 Stimulation. Am. J. Pathol. (2014) 25452118 Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J. (2014) 24891522 |