Strain Data Sheet

RBRC01896

Information1

Image
BRC No.RBRC01896
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6;C3-Mitf<mi-bw>
Former Common nameB6; C3;B6-Mitf-mibw/mibw
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain descriptionThe Mitf, microphthalmia-associated transcription factor plays a critical role in the development of melanocytes, mast cells, osteoclasts and pigmented epithelium. Homozygous mice for the Mitf<mi-bw> mutation display a white coat with black eyes. In this allele, a L1 element was inserted into intron 3. This strain is useful as an animal model for Waardenburg syndrome type 2 (WS2).
Colony maintenanceSibling Mating (Homozygote x Homozygote)
ReferencesHum. Mol. Genet., 8, 1431-1441 (1999). 10400990

Health Report

Examination Date / Room / Racknull

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mitfmicrophthalmia-associated transcription factor6Mitf<mi-bw>black eyed whitemi, wh

Information2

Donor DNA
Research applicationDermatology Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 8, 1431-1441 (1999).
DepositorHiroaki Yamamoto (Tohoku University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Mouse of the Month Dec 2006
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.
Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.
Cancer Res 68(20) 8410-8(2008) 18922914