RBRC01896

Information1

Image
BRC No.RBRC01896
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6;C3-Mitfmi-bw
Former Common nameB6; C3;B6-Mitf-mibw/mibw
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentMitfmi-bw mutant mouse(01262)を元に作製。2004年11月から6Jへの交雑を開始した。交雑開始まではクローズドコロニーで維持。4回目が終了した時点で、rdのアリルは野生型になっている。rdのチェックはPde6bのフラグメントをPCR増幅し制限酵素サイトの有無で判断した。
Strain descriptionThe Mitf, microphthalmia-associated transcription factor plays a critical role in the development of melanocytes, mast cells, osteoclasts and pigmented epithelium. Homozygous mice for the Mitf<mi-bw> mutation display a white coat with black eyes. In this allele, a L1 element was inserted into intron 3. This strain is useful as an animal model for Waardenburg syndrome type 2 (WS2).
Colony maintenanceSibling Mating (Homozygote x Homozygote)
ReferencesHum. Mol. Genet., 8, 1431-1441 (1999). 10400990

Health Report

Examination Date / Room / Rack2008/10/20Room:3-CRack:L
2008/08/25Room:3-CRack:L
2008/06/23Room:3-CRack:L
2008/04/22Room:3-CRack:L
2008/04/21Room:3-CRack:L
2008/02/18Room:3-CRack:L
2007/12/17Room:3-CRack:L
2007/10/15Room:3-CRack:L

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Mitfmicrophthalmia-associated transcription factor6Mitf<mi-bw>black eyed white

Information2

Donor DNA
Research applicationDermatology Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 8, 1431-1441 (1999).
DepositorHiroaki Yamamoto (Tohoku University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Mouse of the Month Dec 2006

BRC mice in Publications

No Data