RBRC01888

Information1

Image
BRC No.RBRC01888
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC57BL/6-Wsh/Wsh
Former Common nameW sash, C57BL/6-W<sh>
H-2 Haplotype
ES Cell line
Background strainC57BL/6J
Appearancewhite, black eyes [a/a B/B C/C Sh/Sh]
black [a/a B/B C/C +/+]
black with white spotting [a/a B/B C/C Sh/+]
Strain developmentDeveloped by Keisuke Oboki, RIKEN Research Center for Allergy anf Immunology. This strain was generated by backcrossing to C57BL/6 from C;B6-a/a-b/b-W<sh>/W<sh> strain (RBRC00762).
Strain descriptionThe Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration.
Colony maintenanceHeteryozygote x Homozygote. Homozygous mutant mice are viable and fertile.
ReferencesBlood, 80, 1448-1453 (1992). 1381627
Blood, 83, 3509-3516 (1994). 7515715
Genet. Res., 39, 315-322 (1982). 7117838
Development, 118, 705-717 (1993). 7521281
Blood, 94, 2658-2666 (1999). 10515869
Am. J. Pathal., 167, 835-848 (2005). 16127161

Health Report

Examination Date / Room / Rack2020/04/06Room:3-6Rack:A
2020/02/03Room:3-6Rack:A
2019/12/02Room:3-6Rack:A
2019/10/16Room:3-6Rack:A
2019/08/05Room:3-6Rack:A
2019/06/03Room:3-6Rack:A
2019/04/01Room:3-6Rack:A
2019/02/04Room:3-6Rack:A

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Kitkit oncogene5Kit<W-Sh>sash

Information2

Donor DNA
Research applicationDermatology Research
Immunology and Inflammation Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorKeisuke Oboki (RIKEN)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (within 1 month)
Additional Info.Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.
Cancer Res. 74(11) 404567(2014) 24879565

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.
Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.
Cancer Res. 68(20) 2376481(2008) 18922914

Kaori Hitomi Satoko Tahara-Hanaoka Haruka Miki Kanako Iwata Shiro Shibayama Masato Kubo Akira Shibuya.
Allergin-1 on mast cells suppresses house dust mite?induced airway hyperresponsiveness in mice.
Int. Immunol. (2018) 30169732

Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI.
Kit-independent mast cell adhesion mediated by Notch.
Int. Immunol. (2018) 30299470

Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.
J. Exp. Med. 209(8) 1493-503(2012) 22826299

Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.
Transcription Factor GATA1 Is Dispensable for Mast Cell Differentiation in Adult Mice.
Mol. Cell. Biol. 34(10) 1812-26(2014) 24615013

Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
Nat Commun (2015) 26159556

Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H.
Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma.
Proc. Natl. Acad. Sci. U.S.A. 108(49) 19802-7(2011) 22106279