Strain Data Sheet

RBRC01874

Strain Information

Image
BRC No.RBRC01874
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameICR.Cg-Tg(CAG-cat,-Bmp2)/YsaRbrc
Former Common nameCAG-CAT-Bmp2
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [c/c]
Strain developmentDeveloped by Dr. Hiroki Kokubo, National Institute of Genetics, Japan in 2004. This strain was maintained under ICR background.
Strain descriptionICR.Cg-Tg(CAG-cat,-Bmp2). In these transgenic mice, The Bmp2, bone morphogenetic protein 2 gene is expressed after excision of the floxed-CAT gene by Cre-mediated recombination.
Colony maintenanceHomozygote x Hemizygote or Crossing to ICR (Jcl:MCH)
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bmp2bone morphogenetic protein 2UNBmp2
  • brachydactyly type A2(MedGEN)

  • hemochromatosis type 1(MedGEN)

  • short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1(MedGEN)
    • catE. coli chloramphenicol acetyltransferase (CAT)UNCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • brachydactyly type A2(MedGEN)

  • hemochromatosis type 1(MedGEN)

  • short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1(MedGEN)
    • loxPphage P1 loxPUNloxP
  • brachydactyly type A2(MedGEN)

  • hemochromatosis type 1(MedGEN)

  • short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), E. coli chloramphenicol acetyltransferase (CAT) gene, phage P1 loxP site, Bmp2 cDNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. Within a period of 2 years after deposition of the material, user must contact the DEPOSITOR and notify him a content of the research. If the DEPOSITOR judges that the research should be a collaborative work, then user must include DEPOSITOR and/or developer's names as co-authors.
    DepositorYumiko Saga (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. CAGGS MTA (English)
    5. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data