RBRC01870

Information1

Image
BRC No.RBRC01870
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameFVB.Cg-Nf2<tm1Gvn>/GvnRbrc
Former Common nameNf2 iso1 KO
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A B/B c/c D/D P/P]
Strain developmentDeveloped by Dr. Marco Giovannini, INSERM France.
Strain descriptionNf2 isoform 1 knock-out mice. Nf2, Neurofiboromatosis type 2 is a tumor suppressor gene encoding a putative cytoskeletal asssociated protein. Homozygous mutant mice are viable and fertile.
Colony maintenanceHomozygote x Homozygote
References

Health Report

Examination Date / Room / Rack2011/04/18Room:3-DRack:J
2011/02/21Room:3-DRack:J
2010/12/13Room:3-DRack:J
2010/10/18Room:3-DRack:J
2010/08/23Room:3-DRack:J
2010/06/21Room:3-DRack:J
2010/04/19Room:3-DRack:J
2010/02/22Room:3-DRack:J

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Nf2neurofibromatosis 211Nf2

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP11loxP

Information2

Donor DNAmouse Nf2 genomic DNA, Phage P1 loxP
Research application
Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use.
RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention.
In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters.
DepositorMarco Giovannini (INSERM)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data