Strain Data Sheet

RBRC01868

Information1

Image
BRC No.RBRC01868
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameFVB.Cg-Ptgds<tm1(cre)Gvn>/GvnRbrc
Former Common namePgds-Cre
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Marco Giovannini, INSERM France.
Strain descriptionPgd2-cre knock-in mouse. A cre recombinase gene was knocked into exon1 of Pgds.
Colony maintenance
ReferencesOncogene, 30(20):2333-2344 (2011). 21242963

Health Report

Examination Date / Room / Racknull

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ptgdsprostaglandin D2 synthase (brain)2Ptgds<tm1.1(cre)Gvn>targeted mutation 1.1, (cre) Marco GiovanniniH-PGDS

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
HBB2rabbit beta-globin polyA2HBB2

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
crePhage P1 Cre recombinase2crePgds

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP2loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Simian virus 40 Large T antigen nuclear localization signal (NLS)2

Information2

Donor DNASimian virus 40 Large T antigen nuclear localization signal (NLS), Phage P1 cre recombinase, Rabbit beta-globin poly A, Phage P1 loxP site, mouse Pgds genomic DNA
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use.
RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention.
In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters.
DepositorMarco Giovannini (INSERM)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY.
Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.
Neuron 103(2) 309-322.e7(2019) 31151773

Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY.
TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
Proc Natl Acad Sci U S A 118(20) (2021) 33972431