RBRC01841

Information1

Image
BRC No.RBRC01841
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(hGOS2)3Noj
Former Common nameAILE1 TG (ATG3)
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. The transgene was injected into the pronuclei of B6D2F1 fertilized eggs. C57BL/6 and DBA/2 mixed (B6 semicongenic).
Strain descriptionThese transgenic mice express human GOS2 (AILE1) gene that was a gene identified as systemic lupus erythematosus (SLE)-upregutated gene by microarray screening.
Colony maintenanceCarrier x Noncarrier [C57BL/6NCrSlc]
ReferencesDNA Res., 15, 253-265 (2008). 18562305
DNA Res., 12, 429-439 (2005). 16769699

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
AILE1augmented expression in SLEUNAILE1CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Information2

Donor DNAhuman Aile1 cDNA, CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
Research applicationMouse Models for Human Disease
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. DNA Res., 12, 429-439 (2005).The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorHiroshi Nojima (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data