RBRC01773

Information1

Image
BRC No.RBRC01773
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S2-Tmbim1<tm1Noj>/26
Former Common nameRECS1 KO
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain developmentDeveloped by Hanjun Zhao, Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2001. D3 ES cells were used to generate the knockout mice.
Strain descriptionRECS1 (Tmbim1) gene knockout mice. The 5’-untranslated sequence (-3.8 kb) and exon 1-6 region of RECS1 was replaced by PGK-neo cassette. Homozygous mutant mice are prone to aortic dilation and cystic medial degeneration (CMD) when the mice ages (older than 14 months). Aortic dilation and CMD are frequently encountered. Viable and fertile.
Colony maintenanceHeterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
ReferencesGenes Genet Syst., 81, 41-50 (2006). 16607040

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tmbim1transmembrane BAX inhibitor motif containing 11Tmbim1<tm1Noj>targeted mutation 1, Hiroshi Nojima

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)1mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAPGK-neo ( ネオマイシン耐性遺伝子 )
Research applicationMouse Models for Human Disease
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. RECS1 deficiency in mice induces susceptibility to cystic medical degeneration. Hanjun Zhao et al. (2006) Genes Genet. Syst. 81, p41-50The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorHiroshi Nojima (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Jan 2007

BRC mice in Publications

No Data