Strain Information | |
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Image | |
BRC No. | RBRC01769 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | 129(B6)-Zfp318<tm1Hhag> |
Former Common name | TZF KO (129), 129-TZF KO, 129(B6)-Zfp318<tm1>/Rbrc |
H-2 Haplotype | |
ES Cell line | D3 [129S2/SvPas] |
Background strain | 129/SvJ |
Appearance | |
Strain development | Developed by Hiromi Hagiwara, Faculty of Biomedical Engineering, Toin University of Yokohama in 2005. |
Strain description | TZF (Zfp318) gene knockout mice. Homozygous males of C57BL/6 background (RBRC01768) have a tendency to exhibit infertile. Homozygous males of 129 background (RBRC01769) are infertile. |
Colony maintenance | Heterozygote x Wild-type [or Crossing to 129X1/SvJJmsSlc] |
References | The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. Inoue A, Ishiji A, Kasagi S, Ishizuka M, Hirose S, Baba T, Hagiwara H Biochem. Biophys. Res. Commun., 273, 398-403 (2000). 10873617A zinc finger protein TZF is a novel corepressor of androgen receptor. Ishizuka M, Kawate H, Takayanagi R, Ohshima H, Tao R H, Hagiwara H Biochem. Biophys. Res. Commun., 331, 1025-1031 (2005). 15882980Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Enders A, Short A, Miosge L A, Bergmann H, Sontani Y, Bertram E M, Whittle B, Balakishnan B, Yoshida K, Sjollema G, Field M A, Andrews T D, Hagiwara H, Goodnow C C Proc. Natl. Acad. Sci. USA, 111, 4513-4518 (2014). 24616512Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2. Tao R H, Kawate H, Wu Y, Ohnaka K, Ishizuka M, Inoue A, Hagiwara H, Takayanagi R Mol. Cell. Endocrinology, 247, 150-165 (2006). 16469430Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis. Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H Biochem. Biophys. Res. Commun., 301, 1079-1085 (2003). 12589823Opposite effects of alternative TZF spliced variants on androgen receptor. Tao R H, Kawate H, Ohnaka K, Ishizuka M, Hagiwara H, Takayanagi R Biochem. Biophys. Res. Commun., 341, 515-521 (2006). 16446156 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
GFP | Green Fluorescent Protein (Aequorea victoria) | 17 | |||||
Zfp318 | zinc finger protein 318 | 17 | Zfp318 | targeted mutation 1, Hiromi Hagiwara | |||
neo | neomycin resistance gene (E. coli) | 17 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, Jellyfish GFP cDNA, mouse TZF genomic DNA |
Research application | Fluorescent Proteins/lacZ System |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. |
Depositor | Hiromi Hagiwara (Toin University of Yokohama) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |