RBRC01767

Information1

Image
BRC No.RBRC01767
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.129S4-Tob1<tm1Tya> Tob2<tm1Tya>/TyaRbrc
Former Common nametob and tob2 KO (B6)
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearance
Strain developmentDeveloped by Dr. Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute at and Dr. Tadashi Yamamoto at the University of Tokyo. This strain was produced by crossing Tob1 KO mice and Tob2 KO mice.
Strain descriptionTob is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob1 null mice are viable and exhibit bone mass due to increased numbers of osteoblasts. While, Tob2 null mice appear normal. This strain is useful for elucidating of Tob gene function.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
References

Health Report

Examination Date / Room / Rack2007/05/22Room:4-ARack:F
2007/05/21Room:4-ARack:F
2007/03/19Room:4-ARack:D
2007/01/15Room:4-ARack:C
2006/11/13Room:4-ARack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tob1transducer of ErbB-2.111Tob1<tm1Tya>targeted mutation 1, Tadashi Yamamoto

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)11mouse phosphoglycerate kinase promoter (PGK promoter)

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tob2transducer of ErbB-2.215Tob2<tm1Tya>targeted mutation 1, Tadashi Yamamoto

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)15

Information2

Donor DNAE. coli neo, mouse PGK promoter, mouse tob genomic DNA, E. coli LacZ, mouse tob2 genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorTadashi Yamamoto (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data