RBRC01766

Information1

Image
BRC No.RBRC01766
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.129S4-Tob2<tm1Tya>/TyaRbrc
Former Common nametob2-gene KO (B6)
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute at and Dr. Tadashi Yamamoto at the University of Tokyo in 1999. LacZ was inserted into Tob2 gene. The mutant mice were backcrossed to C57BL/6J.
Strain descriptionB6.129S4-Tob2<tm1Tya>. Tob gene is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob2 null mice are viable and appear normal. This strain is useful for elucidating of Tob gene function.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
ReferencesGene, 253, 215-220 (2000). 10940559

Health Report

Examination Date / Room / Rack2008/03/17Room:4-ARack:F
2008/01/14Room:4-ARack:F
2007/11/12Room:4-ARack:F
2007/09/18Room:4-ARack:F
2007/07/17Room:4-ARack:F
2007/05/22Room:4-ARack:F
2007/05/21Room:4-ARack:F

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tob2transducer of ErbB-2.215Tob2<tm1Tya>targeted mutation 1, Tadashi Yamamoto

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)15

Information2

Donor DNAE. coli LacZ, mouse tob2 genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorTadashi Yamamoto (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data