RBRC01732

Information1

Image
BRC No.RBRC01732
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameVinexinKO/C57B6
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Noriyuki Kioka, Kyoto University in 2001.
Strain descriptionB6.Cg-Sorbs3<tm>. Sorbs3 (Vinexein) gene is a cytoskeletal protein that plays a key role in the regulation of cytoskeletal organization and signal transduction. This strain is useful for elucidation of the role of the functions of this gene.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc)
ReferencesGenes Cells, 11, 971-982 (2006). 16923119

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Sorbs3sorbin and SH3 domain containing 314Sorbs3<tm1Kmor>targeted mutation 1, Ken-ichirou Morohashi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)14polyoma virus thymidine kinase gene promoter (tk promoter)

Information2

Donor DNAMC1neo (polyoma virus thymidine kinase gene promoter and E. coli neomycin resistance gene) (Developmental Biology, 194, 152-165); mouse vinexin genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorNoriyuki Kioka (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H.
Vinexin-beta deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
J. Neurochem. 134(2) 211-21(2015) 25824575