Strain Data Sheet

RBRC01732

Information1

Image
BRC No.RBRC01732
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Sorbs3<tm1Kmor>/Rbrc
Former Common nameVinexinKO/C57B6
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Noriyuki Kioka, Kyoto University in 2001.
Strain descriptionB6.Cg-Sorbs3<tm>. Sorbs3 (Vinexein) gene is a cytoskeletal protein that plays a key role in the regulation of cytoskeletal organization and signal transduction. This strain is useful for elucidation of the role of the functions of this gene.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc)
ReferencesGenes Cells, 11, 971-982 (2006). 16923119

Health Report

Examination Date / Room / Racknull

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Sorbs3sorbin and SH3 domain containing 314Sorbs3<tm1Kmor>targeted mutation 1, Ken-ichirou MorohashiSh3d4, SH3P3, vinexin alpha, vinexin beta

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)14neo; neomycin;polyoma virus thymidine kinase gene promoter (tk promoter)

Information2

Donor DNAMC1neo (polyoma virus thymidine kinase gene promoter and E. coli neomycin resistance gene) (Developmental Biology, 194, 152-165); mouse vinexin genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorNoriyuki Kioka (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP

BRC mice in Publications

Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H.
Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
J Neurochem 134(2) 211-21(2015) 25824575