Strain Data Sheet

RBRC01727

Strain Information

Image
BRC No.RBRC01727
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6D2;129-Mafa<tm2Staka>/StakaRbrc
Former Common nameMafA KO clone 2
H-2 Haplotype
ES Cell line
Background strainJcl:B6D2F1
Appearance
Strain development
Strain description
Colony maintenance
References
MafA is a key regulator of glucose-stimulated insulin secretion.
Chuan Zhang, Takashi Moriguchi, Miwako Kajihara, Ritsuko Esaki, Ayako Harada, Homare Shimohata, Hisashi Oishi, Michito Hamada, Naoki Morito, Kazuteru Hasegawa, Takashi Kudo, James Douglas Engel, Masayuki Yamamoto, Satoru Takahashi
Mol. Cell. Biol., 25, 4969-4976 (2005). 15923615

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
MafA
MGI:2673307		MAF bZIP transcription factor A15MafA<tm2Staka> targeted mutation 1, Satoru Takahashi
  • islet cell adenomatosis(MedGEN)
    • lacZ beta-galactosidase (E. coli)15
    neo neomycin resistance gene (E. coli)15 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    nls SV40 large T antigen nuclear localization signal (NLS)15nls

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal pancreatic islet morphology (MP:0005215)

  • decreased circulating insulin level (MP:0002727)

  • decreased insulin secretion (MP:0003059)

  • impaired glucose tolerance (MP:0005293)

  • increased circulating glucose level (MP:0005559)
    • more 2 phenotypes
  • increased urine glucose level (MP:0001759)

  • postnatal growth retardation (MP:0001732)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli beta-galactosidase, E. coli neo resistance gene, Simian virus 40 Large T antigen nuclear localization signal (NLS)
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 25, 4969-4976 (2005).
    DepositorSatoru Takahashi (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data